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Antibiotics
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Antimicrobial Resistance and One Health: New Solutions for an Old...
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Antimicrobial Resistance and One Health: New Solutions for an Old Problem?

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1914

Special Issue Editors

Prof. Dr. David Rodríguez-Lázaro

E-Mail Website
Guest Editor
1. Microbiology Division, Faculty of Sciences, University of Burgos, Burgos, Spain
2. Centre for Emerging Pathogens and Global Health, University of Burgos, Burgos, Spain
Interests: food safety; food microbiology; one health; veterinary microbiology; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. José María Eiros-Bouza

E-Mail Website
Guest Editor
Rio Hortega University Hospital, Universidad de Valladolid, 47012 Valladolid, Spain
Interests: antimicrobial resistance; one health; nosocomial infections; micobial genomics and surveillance

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) presents a formidable challenge to global health, agriculture, and ecosystems. As pathogens evolve and adapt, the effectiveness of traditional treatments wanes, leading to increased morbidity, mortality, and healthcare costs. This Special Issue explores the intersection of AMR and the One Health approach, which recognizes the interconnectedness of human, animal, and environmental health. By fostering interdisciplinary collaboration, we aim to highlight innovative strategies and solutions that address the complex dynamics of AMR. Solutions may include enhanced surveillance systems that track resistance patterns across species, improved antibiotic stewardship in healthcare and agriculture, and innovative practices in wastewater management to mitigate environmental impact.

Prof. Dr. David Rodríguez-Lázaro
Prof. Dr. José María Eiros-Bouza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • one health
  • global health
  • surveillance
  • primary porduction
  • food safety
  • environment health
  • nosocomial infections

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Published Papers (2 papers)

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Research

14 pages, 270 KiB  
Article
A One Health Approach Metagenomic Study on Antimicrobial Resistance Traits of Canine Saliva
by Adrienn Gréta Tóth, Darinka Lilla Tóth, Laura Remport, Imre Tóth, Tibor Németh, Attila Dubecz, Árpád V. Patai, Zsombor Wagenhoffer, László Makrai and Norbert Solymosi
Antibiotics 2025, 14(5), 433; https://doi.org/10.3390/antibiotics14050433 - 25 Apr 2025
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Abstract
Background: According to the One Health concept, the physical proximity between pets and their owners facilitates the interspecies spread of bacteria including those that may harbor numerous antimicrobial resistance genes (ARGs). Methods: A shotgun sequencing metagenomic data-based bacteriome and resistome study of 1830 [...] Read more.
Background: According to the One Health concept, the physical proximity between pets and their owners facilitates the interspecies spread of bacteria including those that may harbor numerous antimicrobial resistance genes (ARGs). Methods: A shotgun sequencing metagenomic data-based bacteriome and resistome study of 1830 canine saliva samples was conducted considering the subsets of ARGs with higher public health risk, ESKAPE pathogen relatedness (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), and survey results on the physical and behavioral characteristics of the participating dogs. Results: A total of 318 ARG types achieved sufficiently high detection rates. These ARGs can affect 31 antibiotic drug classes through various resistance mechanisms. ARGs against tetracyclines, cephalosporins, and, interestingly, peptides appeared in the highest number of samples. Other Critically Important Antimicrobials (CIAs, WHO), such as aminoglycosides, fluoroquinolones, or macrolides, were among the drug classes most frequently affected by ARGs of higher public health risk and ESKAPE pathogen-related ARGs of higher public health risk. Several characteristics, including coat color, sterilization status, size, activity, or aggressiveness, were associated with statistically significant differences in ARG occurrence rates (p < 0.0500). Conclusions: Although the oral microbiome of pet owners is unknown, the One Health and public health implications of the close human–pet bonds and the factors potentially underlying the increase in salivary ARG numbers should be considered, particularly in light of the presence of ARGs affecting critically important drugs for human medicine. Full article
(This article belongs to the Special Issue Antimicrobial Resistance and One Health: New Solutions for an Old Problem?)
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21 pages, 2472 KiB  
Article
Genome Analysis of 6222 Bacterial Isolates from Livestock and Food Environments in Spain to Decipher the Antibiotic Resistome
by Marta Hernández, Álvaro Falcó-Prieto, Maria Ugarte-Ruiz, Pedro Miguela-Villoldo, Alain Ocampo-Sosa, David Abad, Marta Pérez-Sancho, Julio Álvarez, Rafael Dorighello Cadamuro, Mariana Alves Elois, Gislaine Fongaro, Alberto Quesada, Bruno González-Zorn, Lucas Domínguez, José M. Eiros and David Rodríguez-Lázaro
Antibiotics 2025, 14(3), 281; https://doi.org/10.3390/antibiotics14030281 - 8 Mar 2025
Viewed by 1184
Abstract
Background/Objectives: Antimicrobial resistance (AMR) poses a significant threat to global health and the economy, with projected costs ranging from $300 billion to $1 trillion annually and an estimated 10 million deaths per year by 2050. The food chain, from primary production to retail, [...] Read more.
Background/Objectives: Antimicrobial resistance (AMR) poses a significant threat to global health and the economy, with projected costs ranging from $300 billion to $1 trillion annually and an estimated 10 million deaths per year by 2050. The food chain, from primary production to retail, represents a critical entry point for antimicrobial resistant bacteria into communities. This underscores the need for a coordinated “One Health” approach, integrating efforts in animal production, environmental health, and human healthcare to address this global concern. This study aimed to characterize the global resistome in Spanish primary production by sequencing 6222 bacterial genomes from animal origin. Methods and Results: Whole genome sequencing was performed on bacterial isolates collected from various farms and analyzed using a validated bioinformatic pipeline. The analysis revealed a diverse range of bacterial species, with Enterobacteriaceae being the most prevalent family. Escherichia coli was the most common species, followed by Salmonella enterica and Pseudomonas aeruginosa. This study identified 1072 antimicrobial resistance genes coding for 43 different classes of resistance, potentially conferring resistance to 81 antimicrobials. Additionally, 79 different plasmid types were detected, highlighting the potential for horizontal gene transfer. Conclusions: The resistome analysis revealed genes conferring resistance to various antibiotic classes, as well as antiseptics, disinfectants, and efflux pump-mediated resistance. This comprehensive characterization of AMR genes circulating in bacteria from primary production provides crucial insights into the ecology of AMR in Spanish livestock. Full article
(This article belongs to the Special Issue Antimicrobial Resistance and One Health: New Solutions for an Old Problem?)
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