Special Issue "Feature Papers in Therapy of Diabetic Foot Infections"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 336

Special Issue Editors

Prof. Dr. Ilker Uckay
E-Mail Website
Guest Editor
Infectiology and Infection Control, Orthopedic Department, Balgrist University Hospital, Zurich, Switzerland
Interests: prevention and treatment of orthopedic infections, including diabetic foot infections
Dr. Laura Soldevila
E-Mail Website
Guest Editor
1. Department of Infectious Diseases, Hospital Universitari de Bellvitge. Barcelona; C/ Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain
2. Infectiology and Infection Control, Balgrist University Hospital, Zurich, Switzerland
Interests: diabetic foot infections; orthopedic infections

Special Issue Information

Dear Colleagues,

Diabetic foot infections (DFIs), soft tissue infections and osteomyelitis alike are multifaceted diseases. Usually, the infection is the tip of the iceberg of a larger, chronic, underlying problem. Hence, the management of all DFIs is multidisciplinary and includes the use of antibiotics, surgery, professional wound care and podiatry, adequate off-loading, re-vascularization, the patient's participation, glycemic control, and many other aspects such as the availability of nationwide policies, guidelines, or local financial and organizational resources. The burden that DFIs represent is high and is expected to rise in the future in virtually every region worldwide

Diabetic foot infections probably represent one of the largest fields of medicine with recurrent antibiotic overuse in relation to their moderate and short-term benefits. There are multiple reasons why therapy fails, ranging from the lack of compliance with off-loading, inadequate debridement, ischemia, the occurrence of a new infection, and the selection of new pathogens, to the recurrence of infection with the same pathogens as those present in a previous episode. However, only true recurrences of infection can definitively be prevented by the use of antibiotic treatment.

Although there is a rising number of scientific publications regarding antibiotic treatments for various subsets of DFI, questions remain: the use of oral versus intravenous versus local antibiotics; the optimal duration of systemic antibiotic therapy, the need for biofilm-acting agents; the costs and side effects of antibiotic use; the promotion of antibiotic resistance through from DFI treatments; as well as difficulties in terms of reimbursement and healthcare policies, which may vary from one country to the other and compromise the overall success of DFI management on a large scale.. Finally, antibiotic stewardship in the DFI population may also include non-antibiotic, diagnostic, and therapeutic measures. This Special Issue addresses these issues in line with antibiotic management in DFIs.

Prof. Dr. Ilker Uckay
Dr. Laura Soldevila
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diabetic foot infection
  • diabetic foot osteomyelitis
  • systemic antibiotic therapy
  • local antibiotic therapy
  • side effects
  • treatment success
  • antibiotic stewardship
  • antibiotic policies and difficulties

Published Papers (1 paper)

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Potential Utility of Ultrasound-Enhanced Delivery of Antibiotics, Anti-Inflammatory Agents, and Nutraceuticals: A Mini Review
Antibiotics 2022, 11(10), 1290; https://doi.org/10.3390/antibiotics11101290 - 22 Sep 2022
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Ultrasound technology has therapeutic properties that can be harnessed to enhance topical drug delivery in a process known as phonophoresis. The literature on this method of drug delivery is currently sparse and scattered. In this review, we explore in vivo and in vitro [...] Read more.
Ultrasound technology has therapeutic properties that can be harnessed to enhance topical drug delivery in a process known as phonophoresis. The literature on this method of drug delivery is currently sparse and scattered. In this review, we explore in vivo and in vitro controlled trials as well as studies detailing the mechanism of action in phonophoresis to gain a clearer picture of the treatment modality and explore its utility in chronic wound management. Upon review, we believe that phonophoresis has the potential to aid in chronic wound management, particularly against complicated bacterial biofilms. This would offer a minimally invasive wound management option for patients in the community. Full article
(This article belongs to the Special Issue Feature Papers in Therapy of Diabetic Foot Infections)
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