Cell Therapy and Tissue Engineering for Orthopedic Applications
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 893
Editors
2. Orthopedics and Sports Medicine, Houston Methodist Hospital, 6445 Main St., Houston, TX 77030, USA
Interests: orthopedic tissue engineering; bone and cartilage regeneration; stem cell therapy; MSC immunomodulation; biomimetic and biodegradable materials; nanomedicine
Interests: orthopedic and sports medicine; cartilage repair and osteoarthritis; cell-based regenerative therapies and orthobiologics; clinical translation and outcomes
Special Issue Information
Dear Colleagues,
Musculoskeletal disorders, including traumatic injuries as well as degenerative, systemic, and inflammatory diseases, remain a leading cause of disability worldwide and still lack durable regenerative solutions. Rapid advances in cell and cell-derived therapy along with bioengineered biomaterials are opening new opportunities to restore tissue function and modulate the inflammatory microenvironment that drives disease progression.
This Special Issue aims to bring together original research articles and comprehensive reviews at the intersection of cell therapy and tissue engineering, accelerating mechanistic understanding and advancing the design, rigorous characterization, and translation of clinically meaningful strategies for orthopedic and sports medicine.
We welcome contributions spanning the full spectrum of musculoskeletal tissues and orthopedic districts, including cartilage and osteochondral defects, bone repair, meniscal and tendon/ligament injuries, intervertebral disc degeneration, and joint-associated conditions. Submissions addressing common pathologies are encouraged, including trauma, osteoarthritis, osteoporosis, osteonecrosis, and inflammatory arthritis.
Topics of interest for this Special Issue include the following:
- Mesenchymal stromal/stem cells (MSCs), induced pluripotent stem cells (iPSCs) and other relevant cell types;
- Cell-derived products, including extracellular vesicles (EVs) and secretome-based strategies;
- 3D culture systems (e.g., spheroids and organoids) and disease-modeling platforms;
- Advanced biomaterials (e.g., injectable systems, scaffolds, composites, and bioprinting) for stabilization, augmentation, therapeutic applications, and controlled delivery;
- Other orthobiologics, including platelet-rich plasma (PRP), micro-fragmented adipose tissue (MFAT), and related biologic formulations.
- Combinatorial approaches integrating cells or cell-derived products with biomaterials.
Dr. Federica Banche-Niclot
Prof. Dr. Patrick McCulloch
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- orthopedics and sports medicine
- musculoskeletal regeneration
- cell therapy
- extracellular vesicles
- biomaterials
- translational research
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