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Bioengineering
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Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future...
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Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 2700

Special Issue Editor

Dr. Philippe Abdel-Sayed

E-Mail Website
Guest Editor
1. Service of Plastic and Reconstructive Surgery, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland
2. STI School of Engineering, Federal Polytechnical School of Lausanne, CH-1015 Lausanne, Switzerland
Interests: tissue engineering; regenerative medicine; bioengineering; burn-wound

Special Issue Information

Dear Colleagues,

Tissue engineering has witnessed significant advancements in recent years, driven by innovative developments and interdisciplinary research. Novel techniques such as 3D bioprinting, organ-on-chip models, and the use of stem cells have revolutionized the ability to fabricate complex tissue structures with enhanced functionality. These developments promise to improve regenerative medicine, offering new hope for the treatment of damaged or diseased tissues. However, the field faces several challenges, including the need for scalable manufacturing processes, ensuring the biocompatibility and long-term viability of engineered tissues, and navigating regulatory pathways for clinical applications. Moreover, integrating vascularization and innervation in large tissue constructs remains a critical hurdle. Despite these challenges, the future of tissue engineering is promising, with ongoing research focusing on personalized medicine, the development of hybrid materials, and the integration of artificial intelligence to optimize design and production processes. This Special Issue of Bioengineering on Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives addresses the evolution of these tissue engineering technologies, as they hold the potential to transform healthcare by providing innovative solutions for tissue repair and replacement, ultimately improving patient outcomes.

Dr. Philippe Abdel-Sayed
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • organ-on-chip
  • stem cells
  • vascularization
  • regeneration
  • tissue engineering
  • scaffold
  • biomaterials
  • organoids
  • ATMP

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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14 pages, 752 KB  
Article
High-Precision Multi-Axis Robotic Printing: Optimized Workflow for Complex Tissue Creation
by Erfan Shojaei Barjuei, Joonhwan Shin, Keekyoung Kim and Jihyun Lee
Bioengineering 2025, 12(9), 949; https://doi.org/10.3390/bioengineering12090949 - 31 Aug 2025
Viewed by 384
Abstract
Three-dimensional bioprinting holds great promise for tissue engineering, but struggles with fabricating complex curved geometries such as vascular networks. Though precise, traditional Cartesian bioprinters are constrained by linear layer-by-layer deposition along fixed axes, resulting in limitations such as the stair-step effect. Multi-axis robotic [...] Read more.
Three-dimensional bioprinting holds great promise for tissue engineering, but struggles with fabricating complex curved geometries such as vascular networks. Though precise, traditional Cartesian bioprinters are constrained by linear layer-by-layer deposition along fixed axes, resulting in limitations such as the stair-step effect. Multi-axis robotic bioprinting addresses these challenges by allowing dynamic nozzle orientation and motion along curvilinear paths, enabling conformal printing on anatomically relevant surfaces. Although robotic arms offer lower mechanical precision than CNC stages, accuracy can be enhanced through methods such as vision-based toolpath correction. This study presents a modular multi-axis robotic embedded bioprinting platform that integrates a six-degrees-of-freedom robotic arm, a pneumatic extrusion system, and a viscoplastic support bath. A streamlined workflow combines CAD modeling, CAM slicing, robotic simulation, and automated execution for efficient fabrication. Two case studies validate the system’s ability to print freeform surfaces and vascular-inspired tubular constructs with high fidelity. The results highlight the platform’s versatility and potential for complex tissue fabrication and future in situ bioprinting applications. Full article
(This article belongs to the Special Issue Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives)
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20 pages, 15019 KB  
Article
Long-Term Histological Evaluation of a Novel Dermal Template in the Treatment of Pediatric Burns
by Zeena Gerster-Barzanji, Vivienne Woodtli, Mira Klix, Thomas Biedermann, Clemens Schiestl, Kathrin Neuhaus, Melinda Farkas, Jivko Kamarachev, Daniel Rittirsch and Sophie Böttcher-Haberzeth
Bioengineering 2024, 11(12), 1270; https://doi.org/10.3390/bioengineering11121270 - 14 Dec 2024
Viewed by 1728
Abstract
For pediatric patients with full-thickness burns, achieving adequate dermal regeneration is essential to prevent inelastic scars that may hinder growth. Traditional autologous split-thickness skin grafts alone often fail to restore the dermal layer adequately. This study evaluates the long-term effect of using a [...] Read more.
For pediatric patients with full-thickness burns, achieving adequate dermal regeneration is essential to prevent inelastic scars that may hinder growth. Traditional autologous split-thickness skin grafts alone often fail to restore the dermal layer adequately. This study evaluates the long-term effect of using a NovoSorb® Biodegradable Temporizing Matrix (BTM) as a dermal scaffold in four pediatric patients, promoting dermal formation before autografting. Pediatric burn patients treated at the University Children’s Hospital Zurich between 2020 and 2022 underwent a two-step treatment involving NovoSorb® BTM application, followed by autografting. Histological analysis, conducted through 22 punch biopsies taken up to 2.6 years post-application, demonstrated robust dermal reorganization, with mature epidermal regeneration and stable dermo-epidermal connections. Immunofluorescence staining showed rapid capillary ingrowth, while extracellular matrix components, including collagen and elastic fibers, gradually aligned over time, mimicking normal skin structure. By 2.6 years, the dermal layer displayed characteristics close to uninjured skin, with remnants of NovoSorb® BTM degrading within five months post-application. This study suggests that NovoSorb® BTM facilitates elastic scar formation, offering significant benefits for pediatric patients by reducing functional limitations associated with inelastic scarring. Full article
(This article belongs to the Special Issue Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives)
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