Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1770

Special Issue Editor


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Guest Editor
1. Service of Plastic and Reconstructive Surgery, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland
2. STI School of Engineering, Federal Polytechnical School of Lausanne, CH-1015 Lausanne, Switzerland
Interests: tissue engineering; regenerative medicine; bioengineering; burn-wound

Special Issue Information

Dear Colleagues,

Tissue engineering has witnessed significant advancements in recent years, driven by innovative developments and interdisciplinary research. Novel techniques such as 3D bioprinting, organ-on-chip models, and the use of stem cells have revolutionized the ability to fabricate complex tissue structures with enhanced functionality. These developments promise to improve regenerative medicine, offering new hope for the treatment of damaged or diseased tissues. However, the field faces several challenges, including the need for scalable manufacturing processes, ensuring the biocompatibility and long-term viability of engineered tissues, and navigating regulatory pathways for clinical applications. Moreover, integrating vascularization and innervation in large tissue constructs remains a critical hurdle. Despite these challenges, the future of tissue engineering is promising, with ongoing research focusing on personalized medicine, the development of hybrid materials, and the integration of artificial intelligence to optimize design and production processes. This Special Issue of Bioengineering on Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives addresses the evolution of these tissue engineering technologies, as they hold the potential to transform healthcare by providing innovative solutions for tissue repair and replacement, ultimately improving patient outcomes.

Dr. Philippe Abdel-Sayed
Guest Editor

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Keywords

  • bioprinting
  • organ-on-chip
  • stem cells
  • vascularization
  • regeneration
  • tissue engineering
  • scaffold
  • biomaterials
  • organoids
  • ATMP

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Published Papers (1 paper)

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Research

20 pages, 15019 KiB  
Article
Long-Term Histological Evaluation of a Novel Dermal Template in the Treatment of Pediatric Burns
by Zeena Gerster-Barzanji, Vivienne Woodtli, Mira Klix, Thomas Biedermann, Clemens Schiestl, Kathrin Neuhaus, Melinda Farkas, Jivko Kamarachev, Daniel Rittirsch and Sophie Böttcher-Haberzeth
Bioengineering 2024, 11(12), 1270; https://doi.org/10.3390/bioengineering11121270 - 14 Dec 2024
Viewed by 1351
Abstract
For pediatric patients with full-thickness burns, achieving adequate dermal regeneration is essential to prevent inelastic scars that may hinder growth. Traditional autologous split-thickness skin grafts alone often fail to restore the dermal layer adequately. This study evaluates the long-term effect of using a [...] Read more.
For pediatric patients with full-thickness burns, achieving adequate dermal regeneration is essential to prevent inelastic scars that may hinder growth. Traditional autologous split-thickness skin grafts alone often fail to restore the dermal layer adequately. This study evaluates the long-term effect of using a NovoSorb® Biodegradable Temporizing Matrix (BTM) as a dermal scaffold in four pediatric patients, promoting dermal formation before autografting. Pediatric burn patients treated at the University Children’s Hospital Zurich between 2020 and 2022 underwent a two-step treatment involving NovoSorb® BTM application, followed by autografting. Histological analysis, conducted through 22 punch biopsies taken up to 2.6 years post-application, demonstrated robust dermal reorganization, with mature epidermal regeneration and stable dermo-epidermal connections. Immunofluorescence staining showed rapid capillary ingrowth, while extracellular matrix components, including collagen and elastic fibers, gradually aligned over time, mimicking normal skin structure. By 2.6 years, the dermal layer displayed characteristics close to uninjured skin, with remnants of NovoSorb® BTM degrading within five months post-application. This study suggests that NovoSorb® BTM facilitates elastic scar formation, offering significant benefits for pediatric patients by reducing functional limitations associated with inelastic scarring. Full article
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