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Bioengineering
Special Issues
Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications
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Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 7076

Special Issue Editors

Prof. Dr. Dipak Maity

E-Mail Website
Guest Editor
1. Nanosystems Development Institute, Indiana University, Indianapolis, IN, USA
2. Department of Chemistry and Chemical Biology, Indiana University, Indianapolis, IN, USA
Interests: nanomaterials; nanomedicine; theranostics (diagnostics and therapeutics); drug delivery; cancer treatment; antimicrobial applications
Prof. Dr. Mangilal Agarwal

E-Mail Website
Guest Editor
Integrated Nanosystems Development Institute (INDI), Biomedical Engineering and Informatics, Indiana University, Indianapolis, IN, USA
Interests: nanomaterials; biosensor; cancer treatment; healthcare applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, Emerging Nanomaterials and Nanotechnology for Biomedical Applications, in the Bioengineering journal aims to explore the cutting-edge research and advancements in nanotechnology, as well as their transformative impact on biomedical science, engineering, and healthcare applications. This Special Issue focuses on innovative nanomaterials and nanoscale technologies designed to address critical challenges, including diagnostics, therapeutics, drug delivery, biosensing, tissue engineering, antimicrobials, and other applications. It seeks to highlight interdisciplinary research that bridges chemistry, materials science, biology, and medicine, fostering new strategies for improving patient outcomes and advancing precision medicine. Through this collection, the Special Issue aims to showcase novel methodologies, applications, and perspectives, emphasizing the potential of nanomaterials and nanotechnology in revolutionizing modern biomedical practices and to accelerate the translation of nanotechnology into practical healthcare solutions.

Prof. Dr. Dipak Maity
Prof. Dr. Mangilal Agarwal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanotechnologies
  • biomedical applications
  • drug delivery systems
  • biosensors
  • tissue engineering
  • cancer therapeutics
  • diagnostics
  • biomedical imaging
  • photothermal therapy
  • chemodynamic therapy
  • cardiovascular diseases
  • infection control
  • neurological diseases
  • orthopedics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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19 pages, 3921 KB  
Article
Curcumin-Functionalized Ag and ZnO Nanoparticles: A Nanotherapeutic Approach for Treating Infections in Diabetic Wounds
by Mahboubeh Dolatyari, Parisa Rostami, Mahya Rostami, Ali Rostami and Hamit Mirtagioglu
Bioengineering 2025, 12(10), 1090; https://doi.org/10.3390/bioengineering12101090 - 9 Oct 2025
Cited by 1 | Viewed by 1494
Abstract
Chronic wounds, such as diabetic ulcers, remain a significant clinical challenge due to high infection risk and delayed healing. This study presents a comprehensive evaluation of a novel wound dressing incorporating curcumin-functionalized silver–zinc oxide (Ag-ZnO) nanoparticles. The formulation was rationally designed based on [...] Read more.
Chronic wounds, such as diabetic ulcers, remain a significant clinical challenge due to high infection risk and delayed healing. This study presents a comprehensive evaluation of a novel wound dressing incorporating curcumin-functionalized silver–zinc oxide (Ag-ZnO) nanoparticles. The formulation was rationally designed based on molecular docking simulations that identified curcumin as a high-affinity ligand for Staphylococcus aureus Protein A. The synthesized nanoparticles demonstrated potent, broad-spectrum antibacterial activity, achieving complete inhibition of multidrug-resistant pathogens, including MRSA, within 60 s. A critical comparative assessment, incorporating an unloaded Ag-ZnO nanoparticle control group, was conducted in both a rabbit wound model and a randomized clinical trial (n = 75 patients). This design confirmed that the enhanced wound-healing efficacy is specifically attributable to the synergistic effect of curcumin combined with the nanoparticles. The curcumin-loaded Ag-ZnO treatment group showed a statistically significant reduction in healing time compared to both standard care and unloaded nanoparticle controls (e.g., medium wounds: 19.6 days vs. 90.6, p < 0.001). These findings demonstrate that curcumin-functionalized Ag-ZnO nanoparticles offer a safe and highly effective therapeutic strategy, providing robust antibacterial action and significantly accelerated wound healing. Full article
(This article belongs to the Special Issue Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications)
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21 pages, 1903 KB  
Article
Unlocking Superior MFH Performance Below Hergt’s Biological Safety Limit: SPION-Based Magnetic Nanoplatforms Deliver High Heating Efficiency at Low AMF
by Atul Sudame and Dipak Maity
Bioengineering 2025, 12(7), 715; https://doi.org/10.3390/bioengineering12070715 - 30 Jun 2025
Cited by 1 | Viewed by 1194
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained significant attention for Magnetic Fluid Hyperthermia (MFH)-based cancer therapy. However, achieving high heating efficiency under a biologically safe Alternating Magnetic Field (AMF) remains a challenge. This study investigates the synthesis and optimization of SPIONs encapsulated in [...] Read more.
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained significant attention for Magnetic Fluid Hyperthermia (MFH)-based cancer therapy. However, achieving high heating efficiency under a biologically safe Alternating Magnetic Field (AMF) remains a challenge. This study investigates the synthesis and optimization of SPIONs encapsulated in TPGS-stabilized PLGA nanoparticles (TPS-NPs) using a modified single emulsion solvent evaporation (M-SESE) method. The aim was to achieve efficient magnetic heating under biologically safe AMF conditions while maintaining biocompatibility and colloidal stability, making these magnetic nanoplatforms suitable for MFH-based cancer treatment. TPS-NPs were characterized using various techniques, including Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), and Superconducting Quantum Interference Device (SQUID) magnetometry, to evaluate their hydrodynamic size (Dh), zeta potential (ζ), encapsulation efficiency, and superparamagnetic properties. Calorimetric MFH studies demonstrated superior heating efficiency, with Specific Absorption Rate (SAR) and Intrinsic Loss Power (ILP) values optimized at an AMF of 4.1 GAm−1s−1, remaining within Hergt’s biological safety limit (~5 GAm−1s−1). These findings suggest that SPION-encapsulated TPS-NPs exhibit enhanced heat induction, making them promising candidates for MFH-based cancer therapy. The study highlights their potential as multifunctional nanoplatforms for magnetic hyperthermia therapy, paving the way for clinical translation in oncology for advanced cancer treatment. Full article
(This article belongs to the Special Issue Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications)
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Review

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28 pages, 814 KB  
Review
Functional Carbon-Based Materials for Blood Purification: Recent Advances Toward Improved Treatment of Renal Failure and Patient Quality of Life
by Abolfazl Mozaffari, Farbod Alimohammadi and Mazeyar Parvinzadeh Gashti
Bioengineering 2025, 12(8), 893; https://doi.org/10.3390/bioengineering12080893 - 21 Aug 2025
Cited by 3 | Viewed by 3673
Abstract
The accumulation of blood toxins, including urea, uric acid, creatinine, bilirubin, p-cresyl sulfate, and indoxyl sulfate, poses severe health risks for patients with renal failure. Effective removal strategies are essential to mitigate complications associated with chronic kidney disease (CKD) and improve patient outcomes. [...] Read more.
The accumulation of blood toxins, including urea, uric acid, creatinine, bilirubin, p-cresyl sulfate, and indoxyl sulfate, poses severe health risks for patients with renal failure. Effective removal strategies are essential to mitigate complications associated with chronic kidney disease (CKD) and improve patient outcomes. Functional carbon-based materials, such as activated carbon (activated charcoal) and graphene oxide, have emerged as promising adsorbents due to their large surface area, adjustable porosity, and biocompatibility. This review comprehensively explores the latest advancements in carbon-based materials for blood purification across three key therapeutic modalities: (1) Hemoperfusion, where activated and modified carbonaceous materials enhance the adsorption of small-molecule and protein-bound toxins; (2) Hemodialysis, where functionalized carbon materials improve clearance rates and reduce treatment duration; and (3) Oral Therapeutics, where orally administered carbon adsorbents show potential in lowering systemic toxin levels in CKD patients. Furthermore, we present a comparative analysis of these approaches, highlighting their advantages, limitations, and future research directions for optimizing carbon-based detoxification strategies. The findings discussed in this review emphasize the significance of material engineering in advancing blood purification technologies. By enhancing the efficiency of toxin removal, carbon-based materials have the potential to revolutionize renal failure treatment, offering improved clinical outcomes and enhanced patient quality of life. Full article
(This article belongs to the Special Issue Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications)
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