Extracellular Vesicles: From Basic Research to Therapeutics

Dear Colleagues,

Extracellular vesicles (EVs) are a heterogeneous mixture of lipid bilayer-bound sacs (30–1000 nm) that contain various classes of nucleic acids and proteins. EVs are classified into three major classes based on size and cellular origin: apoptotic bodies, microvesicles, and exosomes. Exosomes are the smallest vesicle type, between 30 and 200 nm in size, and considered to be more therapeutically relevant. EVs are packed with signaling proteins and coding/regulatory RNAs, and play an important role in maintaining tissue homeostasis by modulating immune system, senescence, proliferation, and differentiation in various biological processes. EVs can be used as a biomarker, drug delivery carriers, and the cell-free therapeutics. Their cargo and surface can be engineered to enhance the therapeutic effects and the targeting specificity. In addition, the culture conditions and systems can affect the EV yield and cargo profiles, which are characterized by multi-omics analysis. This Special Issue focuses on the role of the EVs in therapeutic treatment of various biological disorders.

Prof. Dr. Yan Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.