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Plants, Volume 8, Issue 9 (September 2019)
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Cover Story (view full-size image) Herbicides are small molecules that interact with specific molecular target sites within plant [...] Read more. Herbicides are small molecules that interact with specific molecular target sites within plant biochemical pathways and/or physiological processes. Often, the inhibition of these sites has catastrophic consequences, making these molecules successful weed management tools. There had been a steady discovery of one unique mechanism of action (MOA) every two years from the early 1950s to the mid-1980s. The introduction of glyphosate-resistant crops disrupted discovery programs in most agrichemical companies. However, the evolution of resistance to glyphosate has renewed industries interest in new chemistry interacting with novel target sites. This review analyzes recent characterization of new herbicide target sites, the chemical classes developed to inhibit these target sites, and, where appropriate, the innovative technologies used in these discovery programs. View this paper