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Biomolecules, Volume 10, Issue 6
June 2020 - 156 articles
Cover Story: The activity of the hypothalamic–pituitary–adrenal (HPA) axis, where the dopamine transporter (DAT) plays a key role, is pivotal in homeostasis and orchestrates the adaptative response to stress. DAT−/− ablation in adult female rats causes profound dysregulation of pituitary homeostasis before and after acute restraint stress as well as aberrant autonomic response at respiratory, thermoregulatory, and cardiovascular levels during stress. DAT+/− induces minor changes in pituitary homeostatic mechanisms and hypothermia during stress. We conclude that DAT regulates the HPA axis at the central and peripheral levels, including autonomic function during stress, modulating the vulnerability to stress. Our data provide new insights in the pathophysiology of DAT-related disorders and vulnerability to stress. View this paper
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Biomolecules - ISSN 2218-273X