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Encapsulins—Bacterial Protein Nanocompartments: Structure, Properties, and Application

1
Laboratory “Biomedical Nanomaterials”, National University of Science and Technology “MISiS”, Leninskiy Prospect, 4, 119049 Moscow, Russia
2
Department of Medical Nanobiotechnoilogy, Pirogov Russian National Research Medical University, Ostrovityanova st, 1, 117997 Moscow, Russia
3
Department of Nuclear Medicine, TUM School of Medicine, Technical University of Munich, 81675 Munich, Germany
4
Institute of Biological and Medical Imaging and Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany
5
D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 966; https://doi.org/10.3390/biom10060966
Received: 29 April 2020 / Revised: 21 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue New Trends in Manipulation of Living Cells Behaviour)
Recently, a new class of prokaryotic compartments, collectively called encapsulins or protein nanocompartments, has been discovered. The shell proteins of these structures self-organize to form icosahedral compartments with a diameter of 25–42 nm, while one or more cargo proteins with various functions can be encapsulated in the nanocompartment. Non-native cargo proteins can be loaded into nanocompartments and the surface of the shells can be further functionalized, which allows for developing targeted drug delivery systems or using encapsulins as contrast agents for magnetic resonance imaging. Since the genes encoding encapsulins can be integrated into the cell genome, encapsulins are attractive for investigation in various scientific fields, including biomedicine and nanotechnology. View Full-Text
Keywords: encapsulin; nanocompartment; cell labeling; MRI encapsulin; nanocompartment; cell labeling; MRI
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Gabashvili, A.N.; Chmelyuk, N.S.; Efremova, M.V.; Malinovskaya, J.A.; Semkina, A.S.; Abakumov, M.A. Encapsulins—Bacterial Protein Nanocompartments: Structure, Properties, and Application. Biomolecules 2020, 10, 966.

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