Next Article in Journal
Metabolism of Soy Isoflavones by Intestinal Bacteria: Genome Analysis of an Adlercreutzia equolifaciens Strain That Does Not Produce Equol
Next Article in Special Issue
Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications
Previous Article in Journal
Brain NMDA Receptors in Schizophrenia and Depression
Previous Article in Special Issue
Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling
Open AccessArticle

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

1
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Sukilėlių pr. 15, LT-50161 Kaunas, Lithuania
2
Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania
3
Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 948; https://doi.org/10.3390/biom10060948
Received: 20 May 2020 / Revised: 19 June 2020 / Accepted: 21 June 2020 / Published: 23 June 2020
(This article belongs to the Special Issue Perspectives of Essential Oils)
Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity. We used cardiac surface ECG and a combination of microelectrode and optical mapping techniques to track the action potentials (APs) in the Langendorff-perfused rabbit heart model during atrial/endo-/epi-cardial pacing. Activation time, conduction velocity and AP duration (APD) maps were constructed. E. ciliata increased the QRS duration and shortened QT interval of ECG at concentrations of 0.01–0.1 μL/mL, whereas 0.3 μL/mL (0.03%) concentration resulted in marked strengthening of changes. In addition, the E. ciliata in a concentration dependent manner reduced the AP upstroke dV/dtmax and AP amplitude as well as APD. A marked attenuation of the AP dV/dtmax and a slowing spread of electrical signals suggest the impaired functioning of Na+-channels, and the effect was use-dependent. Importantly, all these changes were at least partially reversible. Our results indicate that E. ciliata modulates cardiac electrical activity preferentially inhibiting Na+ conductance, which may contribute to its effects as a natural antiarrhythmic medicine. View Full-Text
Keywords: E. ciliata essential oil; natural antiarrhythmic medicine; Langendorff-perfused heart; pseudo ECG; action potential; optical mapping E. ciliata essential oil; natural antiarrhythmic medicine; Langendorff-perfused heart; pseudo ECG; action potential; optical mapping
Show Figures

Figure 1

MDPI and ACS Style

Mačianskienė, R.; Pudžiuvelytė, L.; Bernatonienė, J.; Almanaitytė, M.; Navalinskas, A.; Treinys, R.; Andriulė, I.; Jurevičius, J. Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance. Biomolecules 2020, 10, 948.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop