Ubiquitin-Like Modifiers and Their Diverse Impact on Cell Signaling

Dear Colleagues,

The reversible modification of proteins or lipids by ubiquitin-like proteins (UbLs) is a key regulatory process in virtually all aspects of cell physiology. UbLs target thousands of cellular components through homologous and sometimes parallel modification pathways. Together, UbLs constitute an elaborate code involved in multiple intracellular pathways, including general protein turnover, cell cycle progression, transcription, morphogenesis and development, responses to environmental challenges, and enhanced immune response. Aberrations in the UbL code are implicated in multiple human diseases such as cancer, neurodegeneration, developmental and aging disorders, as well as in plant responses to environmental stresses, including pathogen infection, drought, salinity, temperature changes, nutrient deprivation, irradiation and pollution. Recent technological advances in gene manipulations, high-resolution microscopy, mass spectrometry, chemical synthesis, and stem cell utilization coalesce to contribute to potential therapeutic interventions. This Special Issue shares the fantastic recent progress in the field, together with pioneering discoveries.

Dr. Elah Pick
Guest Editor

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