Special Issue "Potential Molecular Targets for Disease—Modifying Therapeutic Strategies in Parkinson’s Disease"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: Parkinson’s disease; mechanisms of neuronal death; alpha-synuclein; immune response; mitochondrial mediated cell death; lysosomal impairment; transcription factor EB; neuroprotective strategies
A century ago, Konstantin Tretiakoff reported that substantia nigra pars compacta was the main anatomical substrate of Parkinson’s disease (PD). So far, scientists in the field have not been able to elucidate the primary cause of neuronal cell death in this pathological condition. Several neuron-autonomous and non-neuron-autonomous mechanisms have been suggested to contribute to neurodegeneration. Mitochondrial dysfunction, oxidative and endoplasmic reticulum stress, impairment of the degradation pathways, protein aggregation, and programmed cell death are some of the neuron-autonomous mechanisms that have been proposed. Among the non-neuron-autonomous mechanisms, neuroinflammation has been the most studied. Even though several strategies targeting some of those mechanisms are neuroprotective in PD animal models, none of the clinical trials carried out to date to halt the progression of the disease have been satisfactory. Therefore, we need to try different approaches if we want different results and to cure this disabling disease.
The goal of this Special Issue is precisely to inspire all of us with new approaches and perspectives regarding potential therapeutic targets and the mechanisms of neuronal cell death in PD. We encourage researchers in the field to contribute review articles on neuron-autonomous and non-neuron-autonomous mechanisms/targets that help us to separate the wheat from the chaff, regardless of whether their hypotheses are mainstream. We are also open to original papers that assess new targets or old targets with new perspectives or methodologies.
Dr. Jordi Bové
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Parkinson’s disease
- neuronal death mechanisms
- targets for neuroprotection
- genetic risk factors