Next Article in Journal
Ethylene: A Master Regulator of Salinity Stress Tolerance in Plants
Previous Article in Journal
Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation
Previous Article in Special Issue
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines
Open AccessReview

The Hyperoxic-Hypoxic Paradox

by Amir Hadanny 1,2,3,* and Shai Efrati 1,2,4
1
The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel
2
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
3
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan 5290002, Israel
4
The Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 6997801, Israel
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 958; https://doi.org/10.3390/biom10060958
Received: 27 May 2020 / Revised: 20 June 2020 / Accepted: 22 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Oxygen Therapy)
Effective metabolism is highly dependent on a narrow therapeutic range of oxygen. Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene expression, metabolic changes, and regenerative processes, including angiogenesis and stimulation of stem cell proliferation, migration, and differentiation. The sensing of decreased oxygen levels (hypoxia) or increased oxygen levels (hyperoxia), occurs through specialized chemoreceptor cells and metabolic changes at the cellular level, which regulate the response. Interestingly, fluctuations in the free oxygen concentration rather than the absolute level of oxygen can be interpreted at the cellular level as a lack of oxygen. Thus, repeated intermittent hyperoxia can induce many of the mediators and cellular mechanisms that are usually induced during hypoxia. This is called the hyperoxic-hypoxic paradox (HHP). This article reviews oxygen physiology, the main cellular processes triggered by hypoxia, and the cascade of events triggered by the HHP. View Full-Text
Keywords: hyperoxia; hypoxia; hyperbaric oxygen; biogenesis; hyperoxic-hypoxic paradox; hypoxia-inducible factor (HIF) hyperoxia; hypoxia; hyperbaric oxygen; biogenesis; hyperoxic-hypoxic paradox; hypoxia-inducible factor (HIF)
Show Figures

Figure 1

MDPI and ACS Style

Hadanny, A.; Efrati, S. The Hyperoxic-Hypoxic Paradox. Biomolecules 2020, 10, 958.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop