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Metabolites, Volume 9, Issue 10

October 2019 - 50 articles

Cover Story: Metabolomics uses high-throughput analytical techniques like MS and NMR to generate high-dimensional and complex experimental data. Open source tools are needed for innovative, open, and reproducible science, and the programming and statistics environment R has become a popular environment to process and analyze metabolomics datasets. A huge benefit of such an environment is the possibility to connect different tools into comprehensive workflows. The review covers more than two hundred metabolomics packages from CRAN, Bioconductor, and GitHub for typical computational metabolomics workflows, including data processing, biostatistics, metabolite annotation and identification, and biochemical network and pathway analysis. View this paper.
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Articles (50)

  • Article
  • Open Access
23 Citations
4,448 Views
13 Pages

21 October 2019

The comprehensive bacterial populations and metabolites profile in fermented feed is unclear, which may have significant effects on the stability of fermented feed quality and animal gut health. In this study, 16S rRNA gene sequencing and liquid chro...

  • Article
  • Open Access
27 Citations
4,451 Views
13 Pages

21 October 2019

Stroke is one of the leading causes of death and long-term disability worldwide. Gross saponins of Tribulus terrestris fruit (GSTTF) has been used for neuroprotective therapy on convalescents of ischemic stroke. But the related therapeutic mechanisms...

  • Article
  • Open Access
58 Citations
9,358 Views
17 Pages

21 October 2019

Illuminating the comprehensive lipid profiles after dietary supplementation of polyunsaturated fatty acids (PUFAs) is crucial to revealing the tissue distribution of PUFAs in living organisms, as well as to providing novel insights into lipid metabol...

  • Review
  • Open Access
71 Citations
16,634 Views
26 Pages

21 October 2019

Inborn errors of metabolism (IEMs) are a group of inherited diseases with variable incidences. IEMs are caused by disrupting enzyme activities in specific metabolic pathways by genetic mutations, either directly or indirectly by cofactor deficiencies...

  • Article
  • Open Access
15 Citations
4,764 Views
8 Pages

WebSpecmine: A Website for Metabolomics Data Analysis and Mining

  • Sara Cardoso,
  • Telma Afonso,
  • Marcelo Maraschin and
  • Miguel Rocha

19 October 2019

Metabolomics data analysis is an important task in biomedical research. The available tools do not provide a wide variety of methods and data types, nor ways to store and share data and results generated. Thus, we have developed WebSpecmine to overco...

  • Article
  • Open Access
9 Citations
4,511 Views
22 Pages

Influence of Dietary Ingredients on Lean Body Percent, Uremic Toxin Concentrations, and Kidney Function in Senior-Adult Cats

  • Jean A. Hall,
  • Matthew I. Jackson,
  • Giosi Farace,
  • Maha Yerramilli and
  • Dennis E. Jewell

19 October 2019

The goal of this study was to determine if modification of currently available maintenance foods with alternative ingredients, botanicals (fruit and vegetables), and increased amounts of functional lipids (fish oil) would delay the age-associated dec...

  • Article
  • Open Access
38 Citations
5,838 Views
27 Pages

Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine

  • Sidney Behringer,
  • Victoria Wingert,
  • Victor Oria,
  • Anke Schumann,
  • Sarah Grünert,
  • Artur Cieslar-Pobuda,
  • Stefan Kölker,
  • Ann-Kathrin Lederer,
  • Donald W. Jacobsen and
  • Judith Staerk
  • + 3 authors

18 October 2019

The concentration of thiol and thioether metabolites in plasma has diagnostic value in genetic diseases of B-vitamin metabolism linked to methionine utilization. Among these, cysteine/cystine (Cys/CSSC) and glutathione/oxidized glutathione (GSH/GSSG)...

  • Article
  • Open Access
14 Citations
3,489 Views
12 Pages

Assessing the Pre-Analytical Stability of Small-Molecule Metabolites in Cerebrospinal Fluid Using Direct-Infusion Metabolomics

  • Hanneke A. Haijes,
  • Eline A.J. Willemse,
  • Johan Gerrits,
  • Wiesje M. van der Flier,
  • Charlotte E. Teunissen,
  • Nanda M. Verhoeven-Duif and
  • Judith J.M. Jans

18 October 2019

Metabolomics studies aiming to find biomarkers frequently make use of historical or multicenter cohorts. These samples often have different pre-analytical conditions that potentially affect metabolite concentrations. We studied the effect of differen...

  • Article
  • Open Access
12 Citations
3,563 Views
14 Pages

Alterations in Exercise-Induced Plasma Adenosine Triphosphate Concentration in Highly Trained Athletes in a One-Year Training Cycle

  • Ewa Anna Zarębska,
  • Krzysztof Kusy,
  • Ewa Maria Słomińska,
  • Łukasz Kruszyna and
  • Jacek Zieliński

16 October 2019

This study aimed to assess the effect of training loads on plasma adenosine triphosphate responsiveness in highly trained athletes in a 1 y cycle. Highly trained futsal players (11 men, age range 20–31 y), endurance athletes (11 men, age range...

  • Article
  • Open Access
18 Citations
4,686 Views
16 Pages

16 October 2019

Alcoholic liver disease (ALD) as a consequence of ethanol chronic consumption could lead to hepatic cirrhosis that is linked to high morbidity and mortality. Disease diagnosis is still very challenging and usually clear findings are obtained in the l...

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Metabolites - ISSN 2218-1989