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Metabolites, Volume 9, Issue 9 (September 2019)
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Cover Story (view full-size image) Actinomycetes are renowned natural product sources, and bioinformatics analyses of genomes from [...] Read more. Actinomycetes are renowned natural product sources, and bioinformatics analyses of genomes from these bacteria support that a plethora of metabolites remain to be unveiled. Discovery of these molecules necessitates tools for recognizing experimental variables that mediate metabolite production. We devised an isotopic ratio outlier analysis strategy to accelerate metabolite discovery by deciphering actinomycete metabolome perturbations in response to environmental changes. Treatment and control samples, fermented under different conditions, were supplemented with an internal standard (I.S.) containing a distinct isotope of all metabolites prior to LC/MS. Comparison of resulting signals for each treatment and control metabolite relative to its isotopic I.S. enabled rapid recognition of metabolites whose production was perturbed. This adds to the analytical toolkit for accessing the metabolic prowess of actinomycetes. View this paper.