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Special Issue "Mitochondria and Metabolism in Disorders"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (31 January 2020).
Interests: skin aging; inflammatory diseases; metabolic reprogramming in cancer; transcriptional regulation; high-throughput approaches for drug and target discovery
Mitochondria are bioenergetic organelles that support cell growth and functions through direct implication in cell signaling and metabolic pathways. These organelles are unique as they control both ATP production and apoptosis, and thus are key deciders of cellular fate. It is now appreciated that mitochondria exhibit structural and metabolic plasticity in response to cellular and microenvironmental contexts, indicating that they play a pivotal role in metabolic adaptation. While mitochondria have been classically isolated and tested under optimized conditions, their constant and dynamic communication with surrounding organelles suggests that their full complexity can only be appreciated in whole cells. Over the past few years, there has been an important progress in the development of new technologies to monitor changes in mitochondrial function in disease. Mitochondrial dysfunction regroups a spectrum of defects associated with altered bioenergetics, oxidative stress, metabolic rewiring, the production of new metabolites, inflammation, and cell death. Besides primary mitochondrial diseases caused by mutations in nuclear or mitochondrial DNA, mitochondrial dysfunction is increasingly recognized has a hallmark of an expanding number of human diseases referred to as secondary mitochondrial diseases. Since mitochondrial dysfunction is shared among a large spectrum of diseases, therapeutic targeting of mitochondria appears as a promising strategy to treat multiple disorders. This Special Issue proposes an exploration of the metabolic bases of disorders characterized by mitochondrial dysfunction. It will introduce state-of-the-art technologies in metabolomics and discuss emerging approaches to study mitochondrial dysfunction. Our objective is to bring together the work of leading researchers to shed light on the current state of mitochondrial research and the challenges associated with the study of mitochondria.
Dr. Simon-Pierre Gravel
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mitochondrial dysfunction
- mitochondrial metabolism
- metabolic flux analysis