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Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota

1
School of Korean Medicine, Dongshin University, Naju 58245, Korea
2
School of Life Sciences, Faculty of Biotechnology, SARI Jeju National University, Jeju 63243, Korea
3
Subtropical/tropical Organism Gene Bank Jeju National University, Jeju 63243, Korea
*
Authors to whom correspondence should be addressed.
These authors equally contributed to the work.
Metabolites 2019, 9(10), 226; https://doi.org/10.3390/metabo9100226
Received: 11 September 2019 / Revised: 10 October 2019 / Accepted: 12 October 2019 / Published: 14 October 2019
(This article belongs to the Special Issue Metabolomics and Microbiota Metabolism)
The objective of this study was to examine the anti-colitis activity of Jakyakgamcho-tang (JGT) in dextran sulfate sodium (DSS)-induced colitis and explore changes of the gut microbial community using 16S rRNA amplicon sequencing and metabolomics approaches. It was found that treatment with JGT or 5-aminosalicylic acid (5-ASA) alleviated the severity of colitis symptoms by suppressing inflammatory cytokine levels of IL-6, IL-12, and IFN-γ. The non-metric multidimensional scaling analysis of gut microbiome revealed that JGT groups were clearly separated from the DSS group, suggesting that JGT administration altered gut microbiota. The operational taxonomic units (OTUs) that were decreased by DSS but increased by JGT include Akkermansia and Allobaculum. On the other hand, OTUs that were increased by DSS but decreased by 5-ASA or JGT treatments include Bacteroidales S24-7, Ruminococcaceae, and Rikenellaceae, and the genera Bacteroides, Parabacteroides, Oscillospira, and Coprobacillus. After JGT administration, the metabolites, including most amino acids and lactic acid that were altered by colitis induction, became similar to those of the control group. This study demonstrates that JGT might have potential to effectively treat colitis by restoring dysbiosis of gut microbiota and host metabolites. View Full-Text
Keywords: Jakyakgamcho-tang; inflammatory bowel disease; microbiota; metabolomics Jakyakgamcho-tang; inflammatory bowel disease; microbiota; metabolomics
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Seo, S.-H.; Unno, T.; Park, S.-E.; Kim, E.-J.; Lee, Y.-M.; Na, C.-S.; Son, H.-S. Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota. Metabolites 2019, 9, 226.

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