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Metabolites, Volume 9, Issue 11 (November 2019)
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Cover Story (view full-size image) We used a lipidomic approach to identify potential lipid mediators of docosahexaenoic acid [...] Read more. We used a lipidomic approach to identify potential lipid mediators of docosahexaenoic acid [DHA]-mediated attenuation of Western diet (WD)-induced nonalcoholic steatohepatitis (NASH). WD-induced NASH in Ldlr - /- mice increases hepatic steatosis, inflammation, fibrosis, membrane arachidonic acid (ARA) content, and formation of ARA-derived pro-inflammatory oxylipins and decreases C20-22 ω3 PUFA-derived anti-inflammatory oxylipins. DHA supplementation of the WD reversed all of these NASH features. While hepatic pro-inflammatory ARA-derived oxylipins were associated with NASH, DHA-mediated attenuation of NASH was associated with increased hepatic C20-22 ω3 PUFA and anti-inflammatory C20-22 ω3 PUFA-derived oxylipins. Hepatic content of ω3 and ω6 PUFA-derived oxylipins may be a good predictor of liver health. View this paper.