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Metabolites, Volume 14, Issue 4

April 2024 - 69 articles

Cover Story: Little is known about lipid changes that occur with MASLD improvement. This study examined lipidome changes in 40 adolescent boys with hepatic steatosis ≥5%, randomized to a low-free sugar diet (LFSD) or usual diet for 8 weeks. Using LC-MS/MS, we observed decreased levels in triglycerides (TGs), diacylglycerols (DGs), cholesteryl esters (ChE), lysophosphatidylcholine (LPC), and phosphatidylcholine (PC) in the LFSD group. Network analysis showed significantly lower levels of palmitate-enriched TG species post-intervention. Targeted oxylipins analysis indicated changes in eicosanoids, with decreased 8-isoprostane and 14,15-DiHET and increased 8,9-DiHET. These lipids are linked to MASLD progression, suggesting potential improvement in lipid metabolism, DNL, insulin resistance, and lipotoxicity. View this paper
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Articles (69)

  • Article
  • Open Access
8 Citations
2,848 Views
19 Pages

Transcriptomic and Lipidomic Analysis Reveals Complex Regulation Mechanisms Underlying Rice Roots’ Response to Salt Stress

  • Yingbin Xue,
  • Chenyu Zhou,
  • Naijie Feng,
  • Dianfeng Zheng,
  • Xuefeng Shen,
  • Gangshun Rao,
  • Yongxiang Huang,
  • Wangxiao Cai,
  • Ying Liu and
  • Rui Zhang

21 April 2024

Rice (Oryza sativa L.), a crucial food crop that sustains over half the world’s population, is often hindered by salt stress during various growth stages, ultimately causing a decrease in yield. However, the specific mechanism of rice roots&rsq...

  • Article
  • Open Access
2 Citations
2,431 Views
17 Pages

A Data-Driven Approach to Sugarcane Breeding Programs with Agronomic Characteristics and Amino Acid Constituent Profiling

  • Chiaki Ishikawa,
  • Yasuhiro Date,
  • Makoto Umeda,
  • Yusuke Tarumoto,
  • Megumi Okubo,
  • Yasujiro Morimitsu,
  • Yasuaki Tamura,
  • Yoichi Nishiba and
  • Hiroshi Ono

21 April 2024

Sugarcane (Saccharum spp. hybrids) and its processed products have supported local industries such as those in the Nansei Islands, Japan. To improve the sugarcane quality and productivity, breeders select better clones by evaluating agronomic charact...

  • Article
  • Open Access
10 Citations
2,558 Views
16 Pages

21 April 2024

The use of different rootstocks has a significant effect on the content of flavor components and overall fruit quality. However, little information is available about the metabolic basis of the nutritional value of citrus plants. In this study, UPLC-...

  • Article
  • Open Access
2,114 Views
14 Pages

Salicylic Acid and Water Stress: Effects on Morphophysiology and Essential Oil Profile of Eryngium foetidum

  • Sabrina Kelly dos Santos,
  • Daniel da Silva Gomes,
  • Vanessa de Azevedo Soares,
  • Estephanni Fernanda Oliveira Dantas,
  • Ana Flávia Pellegrini de Oliveira,
  • Moises Henrique Almeida Gusmão,
  • Elyabe Monteiro de Matos,
  • Tancredo Souza,
  • Lyderson Facio Viccini and
  • Richard Michael Grazul
  • + 2 authors

21 April 2024

The exogenous application of bioregulators, such as salicylic acid (SA), has exhibited promising outcomes in alleviating drought stress. Nevertheless, its impact on culantro (Eryngium foetidum L.) remains unexplored. Thus, the aim of this study was t...

  • Article
  • Open Access
4 Citations
2,820 Views
19 Pages

Comparative Lipidomics of Oral Commensal and Opportunistic Bacteria

  • Paul L. Wood,
  • Annie Le and
  • Dominic L. Palazzolo

20 April 2024

The oral cavity contains a vast array of microbes that contribute to the balance between oral health and disease. In addition, oral bacteria can gain access to the circulation and contribute to other diseases and chronic conditions. There are a limit...

  • Article
  • Open Access
8 Citations
5,556 Views
19 Pages

HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses

  • Danica Bajic,
  • Frank Wiens,
  • Eva Wintergerst,
  • Stef Deyaert,
  • Aurélien Baudot and
  • Pieter Van den Abbeele

20 April 2024

Recent studies suggest that the dietary intake of human milk oligosaccharides (HMOs) provides health benefits from infancy up to adulthood. Thus far, beneficial changes in the adult gut microbiome have been observed at oral doses of 5–20 g/day...

  • Article
  • Open Access
2,815 Views
12 Pages

Anaplerotic Therapy Using Triheptanoin in Two Brothers Suffering from Aconitase 2 Deficiency

  • Maximilian Penkl,
  • Johannes A. Mayr,
  • René G. Feichtinger,
  • Ralf Reilmann,
  • Otfried Debus,
  • Manfred Fobker,
  • Anja Penkl,
  • Janine Reunert,
  • Stephan Rust and
  • Thorsten Marquardt

20 April 2024

Citric acid cycle deficiencies are extremely rare due to their central role in energy metabolism. The ACO2 gene encodes the mitochondrial isoform of aconitase (aconitase 2), the second enzyme of the citric acid cycle. Approximately 100 patients with...

  • Article
  • Open Access
3,594 Views
21 Pages

19 April 2024

Since hop secondary metabolites have a direct correlation with the quality of beer and other hop-based beverages, and the volatile fraction of hop has a complex composition, requiring effective separation, here we explore the application of headspace...

  • Article
  • Open Access
9 Citations
2,448 Views
27 Pages

19 April 2024

This study evaluated effects of high starch (20%) on hematological variations, glucose and lipid metabolism, antioxidant ability, inflammatory responses, and histopathological lesions in largemouth bass. Results showed hepatic crude lipid and triacyl...

  • Article
  • Open Access
3 Citations
2,695 Views
14 Pages

Development of New Predictive Equations for the Resting Metabolic Rate (RMR) of Women with Lipedema

  • Małgorzata Jeziorek,
  • Jakub Wronowicz,
  • Łucja Janek,
  • Krzysztof Kujawa and
  • Andrzej Szuba

19 April 2024

This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland. RM...

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Metabolites - ISSN 2218-1989