Metabolic Cancer Therapy: Targeting Tumor Metabolism for Innovative Adjuvant Treatment
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 2239
Special Issue Editor
Interests: ketogenic; diet; low-carb diet; mitochondrial dysfunction; adjuvant metabolic therapy; diabetes; obesity; cancer nutritional support
Special Issue Information
Dear Colleagues,
A possible emerging approach to cancer treatment involves the targeting of aberrant tumor metabolism. The metabolic changes that occur throughout the progression of cancer provide distinct characteristics that can be used for therapeutic purposes, specifically targeting the metabolic demands of neoplastic cells for essential nutrients. As no tumor can grow without anabolic substrates or energy, their simultaneous inhibition could ultimately reduce the viability of most, if not all, neoplastic cells. Normal eukaryotic animal cells are metabolically flexible and can generate energy using substrate-level phosphorylation or mitochondrial oxidative phosphorylation, based on the availability of oxygen. Otherwise, cancer cells are largely dependent on the substrate-level phosphorylation of glucose and glutamine through the glycolysis and glutaminolysis pathways, regardless of the presence of oxygen. Exploiting these specific energy and metabolic characteristics of neoplastic cells, it is possible to implement a nutritional and pharmacological intervention aimed at reducing the main substrate-level phosphorylation energy substrates, i.e. glucose and glutamine, in order to obtain the production of non-fermentable substrates by neoplastic cells (e.g., ketone bodies) due to cancer’s mitochondrial dysfunction. This Special Issue will explore the therapeutic possibilities that emerge from cancer-disrupted metabolism and metabolic communication, acting through nutritional, metabolic, and pharmaceutical approaches, to precisely target abnormal tumor metabolism.
Dr. Raffaele Ivan Cincione
Guest Editor
Manuscript Submission Information
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Keywords
- cancer metabolism
- glycolysis
- glutaminolysis
- ketone bodies
- mitochondrial dysfunction
