Lipidomics in Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1631

Special Issue Editor


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Guest Editor
Metabolomics Unit, Lincoln Memorial University, Harrogate, TN, USA
Interests: metabolomics; lipidomics of diseases; disease models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is an invitation to submit research articles and reviews regarding the ever-increasing utility of lipidomics in medical and veterinary research.

Lipidomics is a specialized subfield of metabolomics, with research in this area expanding at a rapid rate. This includes basic and clinical research efforts. As a result, there are a number of potential lipid biomarkers that are under intense study in the fields of oncology, infectious diseases, neurology, and psychiatry. These are biomarkers of disease, of disease progression, and of disease response to therapy. In addition, biomarkers offer the potential to stratify patient subgroups and define new molecular targets for therapeutic intervention. Lipids are multifunctional in that they serve as energy stores, as structural biomolecules in membranes, and in signal transduction pathways. In addition, there are highly specialized lipids that serve unique compartmentalized biological functions.

Analytical advancements, particularly electrospray ionization high-resolution mass spectrometry (ESI-HR-MS), have enabled sampling across a broad domain of these lipids utilizing direct-flow analyses and the introduction of samples by chromatographic methods. Tandem mass spectrometry is also essential for validating the structures of the monitored lipids.

In summary, lipidomics is a fast-paced research field in which HR-MS and mass spectrometric lipid imaging further our knowledge of lipid dynamics, the cellular ultrastructure of lipid pools, and lipid alterations in disease. Decades of exciting research lie ahead for this field.

With this invitation, we solicit research related to basic research, lipidomics methodology, clinical diagnostics, and clinical therapies. In particular, we invite reviews of alternate analytical strategies, data validation, and available lipid databases to be submitted.

Prof. Dr. Paul Wood
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipidomics
  • high-resolution mass spectrometry
  • lipid derivatization
  • lipid chromatography
  • diagnostics
  • therapeutics

Published Papers (2 papers)

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19 pages, 2039 KiB  
Article
Comparative Lipidomics of Oral Commensal and Opportunistic Bacteria
by Paul L. Wood, Annie Le and Dominic L. Palazzolo
Metabolites 2024, 14(4), 240; https://doi.org/10.3390/metabo14040240 - 20 Apr 2024
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Abstract
The oral cavity contains a vast array of microbes that contribute to the balance between oral health and disease. In addition, oral bacteria can gain access to the circulation and contribute to other diseases and chronic conditions. There are a limited number of [...] Read more.
The oral cavity contains a vast array of microbes that contribute to the balance between oral health and disease. In addition, oral bacteria can gain access to the circulation and contribute to other diseases and chronic conditions. There are a limited number of publications available regarding the comparative lipidomics of oral bacteria and fungi involved in the construction of oral biofilms, hence our decision to study the lipidomics of representative oral bacteria and a fungus. We performed high-resolution mass spectrometric analyses (<2.0 ppm mass error) of the lipidomes from five Gram-positive commensal bacteria: Streptococcus oralis, Streptococcus intermedius, Streptococcus mitis, Streptococcus sanguinis, and Streptococcus gordonii; five Gram-positive opportunistic bacteria: Streptococcus mutans, Staphylococcus epidermis, Streptococcus acidominimus, Actinomyces viscosus, and Nanosynbacter lyticus; seven Gram-negative opportunistic bacteria: Porphyromonas gingivalis. Prevotella brevis, Proteus vulgaris, Fusobacterium nucleatum, Veillonella parvula, Treponema denticola, and Alkermansia muciniphila; and one fungus: Candida albicans. Our mass spectrometric analytical platform allowed for a detailed evaluation of the many structural modifications made by microbes for the three major lipid scaffolds: glycerol, sphingosine and fatty acyls of hydroxy fatty acids (FAHFAs). Full article
(This article belongs to the Special Issue Lipidomics in Health and Disease)
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17 pages, 1309 KiB  
Review
The Role of Lysophospholipid Metabolites LPC and LPA in the Pathogenesis of Chronic Obstructive Pulmonary Disease
by Qiqiang Zhou, Yahong Chen, Ying Liang and Yongchang Sun
Metabolites 2024, 14(6), 317; https://doi.org/10.3390/metabo14060317 - 31 May 2024
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Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on individual differences and the phenotypes of the disease. Therefore, exploring or [...] Read more.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on individual differences and the phenotypes of the disease. Therefore, exploring or identifying potential therapeutic targets for COPD is urgently needed. In recent years, there has been growing evidence showing that lysophospholipids, namely lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), can play a significant role in the pathogenesis of COPD. Exploring the metabolism of lysophospholipids holds promise for understanding the underlying mechanism of COPD development and developing novel strategies for COPD treatment. This review primarily concentrates on the involvement and signaling pathways of LPC and LPA in the development and progression of COPD. Furthermore, we reviewed their associations with clinical manifestations, phenotypes, and prognosis within the COPD context and discussed the potential of the pivotal signaling molecules as viable therapeutic targets for COPD treatment. Full article
(This article belongs to the Special Issue Lipidomics in Health and Disease)
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