Toxicity and Ecotoxicity Mechanisms of Heavy Metals on Human Health and Environment

Dear Colleagues,

Many metals are essential for living organisms, but at higher doses, they may be toxic and carcinogenic. Metal exposure occurs mainly in occupational settings and through the environmental contamination of drinking water, air pollution and foods, which can result in serious health problems, such as cancer or many others deleterious impacts on metabolism. Arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr) and nickel (Ni) are classified as Group 1 carcinogens by the International Agency for Research on Cancer. Zinc (Zn), copper (Cu) and aluminium (Al) are also frequent costal contaminants, leading to health problems in marine organisms. This Special Issue will elucidate the molecular mechanisms of metal-induced carcinogenesis and other metabolic disorders and will focus on a variety of pathways, including genotoxicity, mutagenesis, oxidative stress, epigenetic modifications such as DNA methylation, histone post-translational modification and alterations in microRNA regulation, competition with essential metal ions, disorders of energy metabolism, amino acid metabolism, osmoregulation, and cancer-related signaling pathways. This Special Issue takes a broader perspective and aims to assist in guiding future research, with respect to the prevention and therapy of metal exposure in living organisms with diseases including cancer, neurotoxicity, cardiovascular disease, chronic disease, coronary artery disease and different metabolic disorders.

Dr. Rashid Mir
Prof. Dr. Marianne Graber
Guest Editors

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