Effects of Chemical Exposure on Endocrine and Reproductive Functions

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 679

Special Issue Editors


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Guest Editor
Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Parana 85040-080, Brazil
Interests: endocrine-disrupting chemicals; male reproductive biology; thyroid hormones; hypothalamic-pituitary testicular and thyroid axes

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Guest Editor
Department of Biological Sciences, Federal University of Sao Paulo, Sao Paulo 05508-000, Brazil
Interests: thyroid physiology and pathology; endocrine disruptors; epigenetics
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Special Issue Information

Dear Colleague,

Endocrine-disrupting chemicals (EDCs) have been implicated as the cause of several disorders, both in the reproductive sphere and in endocrine aspects such as metabolic regulation. Today, the recognized drop in fertility of the male population and the increasing incidence of female reproductive pathologies, such as polycystic ovary syndrome, has been associated with exposure to endocrine disruptors that affect individuals from conception and pregnancy to puberty and throughout adulthood as well. Furthermore, the increased incidence of metabolic disorders, such as obesity and diabetes, may also be associated with exposure to these agents. For example, these compounds may interfere with the normal mechanisms for regulating glycemic homeostasis or producing hormones that regulate basal metabolism. Therefore, this Special Issue aims to explore the association between exposure to EDCs and the possible development of endocrinopathies. We will accept submissions of reviews, basic sciences, and clinical studies.

Prof. Dr. Renata Marino Romano
Dr. Caroline Serrano-Nascimento
Guest Editors

Manuscript Submission Information

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Keywords

  • endocrine-disrupting chemicals exposure impact on metabolic diseases
  • reproductive failure
  • infertility
  • endocrine disorders

Published Papers (1 paper)

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Research

16 pages, 2868 KiB  
Article
A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals
by Jeane Maria Oliveira, Jamilli Zenzeluk, Caroline Serrano-Nascimento, Marco Aurelio Romano and Renata Marino Romano
Metabolites 2024, 14(4), 226; https://doi.org/10.3390/metabo14040226 - 16 Apr 2024
Viewed by 451
Abstract
Compounds of natural or synthetic origin present in personal care products, food additives, and packaging may interfere with hormonal regulation and are called endocrine-disrupting chemicals (EDCs). The thyroid gland is an important target of these compounds. The objective of this study was to [...] Read more.
Compounds of natural or synthetic origin present in personal care products, food additives, and packaging may interfere with hormonal regulation and are called endocrine-disrupting chemicals (EDCs). The thyroid gland is an important target of these compounds. The objective of this study was to analyze public data on the human thyroid transcriptome and investigate potential new targets of EDCs in the embryonic and adult thyroid glands. We compared the public transcriptome data of adult and embryonic human thyroid glands and selected 100 up- or downregulated genes that were subsequently subjected to functional enrichment analysis. In the embryonic thyroid, the most highly expressed gene was PRMT6, which methylates arginine-4 of histone H2A (86.21%), and the downregulated clusters included plasma lipoprotein particles (39.24%) and endopeptidase inhibitory activity (24.05%). For the adult thyroid gland, the most highly expressed genes were related to the following categories: metallothionein-binding metals (56.67%), steroid hormone biosynthetic process (16.67%), and cellular response to vascular endothelial growth factor stimulus (6.67%). Several compounds ranging from antihypertensive drugs to enzyme inhibitors were identified as potentially harmful to thyroid gland development and adult function. Full article
(This article belongs to the Special Issue Effects of Chemical Exposure on Endocrine and Reproductive Functions)
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