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Metabolites, Volume 10, Issue 3

March 2020 - 43 articles

Cover Story: We used a systems biological approach combining gene expression and metabolomics across tissues and biofluids together with metagenomics of gut microbial diversity. Here, we present the multi-omics study on liver, muscle, adipose tissue, urine, plasma, and feces on mice fed a high-fat diet (HFD). The integration of metabolomics data across tissues and biofluids identified major differences in the liver TCA cycle supported by gene expression analysis of TCA-related enzymes. Investigations of the microbiome showed enrichment of specific species in the HFD group. Our findings help to elucidate how the whole organism metabolome and transcriptome are integrated and regulated during obesity. View this paper.
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Articles (43)

  • Review
  • Open Access
31 Citations
5,737 Views
14 Pages

24 March 2020

There is an ever-increasing appreciation for our gut microbiota that plays a crucial role in the maintenance of health, as well as the development of disease. Probiotics are live bacteria that are consumed to increase the population of beneficial bac...

  • Article
  • Open Access
45 Citations
8,502 Views
26 Pages

Comparative Metabolomics and Molecular Phylogenetics of Melon (Cucumis melo, Cucurbitaceae) Biodiversity

  • Annick Moing,
  • J. William Allwood,
  • Asaph Aharoni,
  • John Baker,
  • Michael H. Beale,
  • Shifra Ben-Dor,
  • Benoît Biais,
  • Federico Brigante,
  • Yosef Burger and
  • Catherine Deborde
  • + 26 authors

24 March 2020

The broad variability of Cucumis melo (melon, Cucurbitaceae) presents a challenge to conventional classification and organization within the species. To shed further light on the infraspecific relationships within C. melo, we compared genotypic and m...

  • Article
  • Open Access
10 Citations
4,448 Views
20 Pages

Deriving Lipid Classification Based on Molecular Formulas

  • Joshua M. Mitchell,
  • Robert M. Flight and
  • Hunter N.B. Moseley

24 March 2020

Despite instrument and algorithmic improvements, the untargeted and accurate assignment of metabolites remains an unsolved problem in metabolomics. New assignment methods such as our SMIRFE algorithm can assign elemental molecular formulas to observe...

  • Article
  • Open Access
14 Citations
3,839 Views
12 Pages

23 March 2020

Various species of globeflowers, belonging to the genus Trollius, have been extensively used in traditional Chinese medicine due to their anti-inflammatory, antimicrobial, and antiviral properties, which are mainly attributed to their high polyphenol...

  • Article
  • Open Access
5 Citations
3,248 Views
15 Pages

21 March 2020

Stable isotope resolved metabolomics (SIRM) experiments use stable isotope tracers to provide superior metabolomics datasets for metabolic flux analysis and metabolic modeling. Since assumptions of model correctness can seriously compromise interpret...

  • Communication
  • Open Access
20 Citations
3,635 Views
7 Pages

20 March 2020

In this communication, we aim to summarize the role of estrogen receptor beta (ERβ) in lipid metabolism in the main metabolic organs with a special focus on sex differences. The action of ERβ is tissue-specific and acts in a sex-dependent m...

  • Article
  • Open Access
32 Citations
6,328 Views
24 Pages

Nematode-Trapping Fungi Produce Diverse Metabolites during Predator–Prey Interaction

  • Ting-Hao Kuo,
  • Ching-Ting Yang,
  • Hsin-Yuan Chang,
  • Yen-Ping Hsueh and
  • Cheng-Chih Hsu

20 March 2020

Nematode-trapping fungi are natural antagonists of nematodes. These predatory fungi are capable of switching their lifestyle from a saprophytic to predatory stage in the presence of nematodes by developing specialized trapping devices to capture and...

  • Article
  • Open Access
46 Citations
5,896 Views
20 Pages

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

  • Vuanghao Lim,
  • Sara Ghorbani Gorji,
  • Venea Dara Daygon and
  • Melissa Fitzgerald

19 March 2020

Selected Australian native fruits such as Davidson’s plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the c...

  • Review
  • Open Access
28 Citations
6,393 Views
15 Pages

Protective Role of Vitamin D in Renal Tubulopathies

  • Guido Gembillo,
  • Valeria Cernaro,
  • Rossella Siligato,
  • Francesco Curreri,
  • Antonino Catalano and
  • Domenico Santoro

19 March 2020

Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic in...

  • Article
  • Open Access
11 Citations
3,766 Views
10 Pages

16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens

  • Daniel Schultz,
  • Surabhi Surabhi,
  • Nicolas Stelling,
  • Michael Rothe,
  • KoInfekt Study Group,
  • Karen Methling,
  • Sven Hammerschmidt,
  • Nikolai Siemens and
  • Michael Lalk

18 March 2020

Respiratory tract infections are a global health problem. The main causative agents of these infections are influenza A virus (IAV), Staphylococcus aureus (S. aureus), and Streptococcus pneumoniae (S. pneumoniae). Major research focuses on genetics a...

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Metabolites - ISSN 2218-1989