Cosmetics, Volume 12, Issue 5

Melanin, the principal component of skin pigmentation, is produced through tyrosinase activity. Recently, supersulphides have been identified in human cells and found to play a role in maintaining cellular activities. Glutathione trisulphide (GSSSG),...

In the original publication [...]

To address the limitation of traditional broad-spectrum antimicrobial agents in compromising skin microbiota homeostasis, this study developed Lactobacillus plantarum fermented milk (FM) as an innovative strategy for selectively regulating microbial...

This study investigates the development and evaluation of anti-photoaging creams enriched with natural extracts from avocado, apple, and kiwi by-products, with and without nanobubbles (NBs), focusing on their antioxidant, photoprotective, anti-inflam...

Reactive oxygen species (ROS) and mitochondrial dysfunction play a major role in skin aging. Due to Tropaeolum majus’ suggested protective actions against ROS, a link between T. majus extract and increased cytoglobin (CYGB) expression was evalu...

Fatty amines are nitrogen-containing organic compounds synthesized from fatty acids, olefins, or alcohols, typically derived from natural oils or petrochemical sources. These molecules generally feature long hydrophobic alkyl chains ranging from C8 t...

Oculocutaneous albinism (OCA) increases susceptibility to ultraviolet (UV) skin damage, skin cancer risk, and psychosocial burden. Data from Madagascar are lacking. We conducted a six-month pilot study (July–December 2024) in northern Madagasca...

Chronic dermatological conditions such as acne vulgaris, androgenetic alopecia (AGA), and alopecia areata (AA) affect hundreds of millions worldwide and contribute substantially to quality-of-life impairment. Despite the availability of systemic reti...

Curcumin (Cur), a natural polyphenolic compound with potent antioxidant and anti-inflammatory properties, faces significant challenges in cosmeceutical applications due to its poor aqueous solubility and low bioavailability. Nanotechnology offers a p...

Valorization of Phoenix dactylifera L. (date) seeds, an abundant agro-industrial byproduct, offer a sustainable approach to developing multifunctional ingredients for dermocosmetic photoprotection. Rich in polyphenols, flavonoids, and lipophilic anti...

Wound healing dysregulation often results in visible scarring with significant psychological impact, particularly affecting individuals with darker skin phototypes. This study investigates the efficacy of an aqueous extract of Australian Jellybush ho...

Peptides are widely used in cosmetic formulations to stimulate extracellular matrix (ECM) synthesis, while silybin (a flavonolignan from Silybum marianum) offers retinol-like benefits through antioxidant and photoprotective activity. This study evalu...

Hyaluronic acid (HA) fillers and botulinum toxin remain among the most frequently requested non-surgical esthetic procedures, due to their favorable safety profile and ability to restore volume and improve skin quality. However, variability in produc...

Semaglutide-induced facial changes, or “Ozempic face” popularized by media, have gained increasing recognition since the widespread and growing use of Ozempic (semaglutide) for weight loss. It refers to facial volume depletion and soft ti...

Background: Contemporary dermatology and cosmetology continue to explore effective strategies for normalizing the function of oily skin, where excessive sebum production and impairment of the hydrolipid barrier pose considerable therapeutic challenge...

The growing demand for dermocosmetics with ingredients of natural origin reflects the pivotal role of cutaneous health and appearance in consumer self-esteem. Under this context, clays have attracted attention for their potential applications in derm...

This study presents the formulation of two natural antioxidant creams based on an oil-in-water emulsion system, incorporating either hydroxycitrate (HCA) from Garcinia cambogia (Gaertn.) or red wine powder (RWP) derived from Aglianico del Vulture red...

Acne vulgaris is a multifactorial disease with high heritability, but the genetic determinants of severity remain incompletely defined. This study evaluated 650 individuals genotyped with a 60-single-nucleotide polymorphism (SNP) panel covering immun...

Quality skin has long been a symbol of health and attractiveness, reflecting both genetic and environmental influences. Multiple elements contribute to beautiful skin. This complex topic influences modern dermatological practices and skincare approac...

Air pollution is known to affect skin health, but tools to objectively measure individual exposure based on skin responses are limited. This study introduces the Exposure Intensity Index (EII), a novel tool that correlates lifestyle-related pollution...

Dermoscopy is an essential, non-invasive diagnostic tool that has transformed the evaluation of pigmented skin lesions and is nowadays also increasingly recognized for its utility in general dermatology. Originally developed for the early detection o...

Hydroxychloroquine (HCQ), an antimalarial commonly used in autoimmune and dermatological conditions, may exert photoprotective effects, though its role against high-energy visible light (HEVL) remains underexplored. This study evaluated HCQ’s i...

Facial aging results from intrinsic and extrinsic factors causing soft tissue volume loss, skin laxity, and wrinkles; minimally invasive fillers combining calcium hydroxyapatite (CaHA) and hyaluronic acid (HA) may mitigate these changes. This pilot s...

Silybum marianum L., commonly known as milk thistle, is traditionally recognized for its hepatoprotective properties. This is primarily due to silymarin, a mixture of flavonolignans with strong antioxidant and anti-inflammatory activities. Although m...

(1) Background: The pursuit of ingredients that possess both anti-melanogenesis and post-inflammatory hyperpigmentation (PIH) prevention effects has become a new research frontier in cosmetics, though there is little work on plant extract-derived ing...

Products with biologically active ingredients have emerged as a powerful category within the skincare and anti-aging sectors. Bridging the gap between pharmaceuticals and cosmetics, they offer therapeutic benefits supported by scientific evidence whi...

The integration of nanotechnology with green chemistry presents sustainable strategies for developing multifunctional cosmeceutical formulations. In this study, iron oxide nanoparticles (IONPs) were successfully synthesized using antioxidant-rich gre...

Background: Hormonal fluctuations significantly influence skin physiology, affecting collagen production, sebum regulation, pigmentation, and tissue repair. Hormonal therapies are increasingly used in cosmetic dermatology to address age-related and h...

This review concentrates on the bioactive potential of two significant agri-food by-products: coffee by-products (coffee pulp and husk, spent coffee grounds, and silverskin) and olive by-products (olive mill wastewater, pomace, stones, and leaves). T...

Human skin microbiome plays a fundamental role in maintaining skin health, immunity, and appearance. While current microbiome-friendly cosmetics emphasize the use of probiotics and prebiotics, recent advances in bioengineering are paving the way for...

Background: Nicotinamide mononucleotide (NMN) has gained attention as an anti-aging compound due to its ability to replenish NAD⁺ levels, which typically decline with age and stress. While improvements in skin conditions have been reported, clinical...

Moisturizers are key components of skincare products, and reliable test methods are essential for evaluating their barrier-repairing and hydrating efficacy. However, the viscous and waxy nature of many cosmetic moisturizers limits the applicability o...

Recent advancements in cosmetic science and personal care represent a fundamental shift from conventional esthetics toward integrative solutions that support both physical health and emotional well-being. This review highlights the latest innovations...

Background: Cutaneous aging is a multifactorial process, increasingly understood through the lens of cellular senescence, a state of stable cell cycle arrest accompanied by a pro-inflammatory secretory phenotype that disrupts tissue homeostasis. Rece...

Microalgae and cyanobacteria produce extracellular polysaccharides that are exuded and released into the medium, typically referred to as exopolysaccharides (EPSs). Microalgae-derived EPSs have garnered attention in the last decade, as they may exhib...

Laser-assisted exosome delivery (LAED) combines ablative fractional lasers with immediate topical application of exosomes. Here, we introduce the LAED concept and report two uncontrolled feasibility observations: a 62-year-old man with atrophic acne...

European legislation defines cosmetics as substances or mixtures designed to contact external body parts for cleaning, protection, fragrance, maintenance, or appearance modification. Cosmetic regulation has become increasingly important in recent yea...

Cnidium officinale (CO) and Angelica gigas (AG) are traditional herbal medicines known for their bioactive compound ferulic acid (FA), which exerts skin-whitening, anti-inflammatory, antioxidant, and UV-protective effects. However, conventional extra...

Silicon (Si) plays a crucial role in maintaining the structural integrity of nails, skin, and hair by supporting collagen synthesis and keratin stability. Despite its recognized benefits, effective topical delivery methods remain underexplored. This...

Cosmeceutical systems represent next-generation topical platforms designed to deliver bioactive molecules with therapeutic potential directly to the skin. This study evaluated four anti-wrinkle formulations (three creams and one emulgel) in terms of...

Background: Skin cancer represents one of the most prevalent malignancies worldwide, with melanoma accounting for approximately 75% of skin cancer-related deaths despite comprising fewer than 5% of cases. Early detection dramatically improves surviva...

Background: Dark-base hair fibers with Curl Pattern (CP) types 2 and 3 from Asian and European populations, respectively, are very similar, although each presents different behaviors regarding water diffusion and cosmetic treatments, including in rel...

The potent sensitizer PPD is considered a key sensitizer in hair dye contact allergy. Modification of its molecular structure to 2-methoxymethyl-p-phenylenediamine (ME-PPD) reduces its skin sensitizing potency. We investigated the usage, behavior, an...

Extracellular vesicles (EVs) have gained attention in the cosmetics industry for their role in intercellular communication and tissue regeneration. They transfer bioactive molecules such as proteins, lipids, and nucleic acids, promoting skin repair,...

Inter-individual variability in response to androgenetic alopecia (AGA) therapies remains a therapeutic challenge. This study evaluated the clinical and mechanistic utility of a 26-SNP pharmacogenetic panel in guiding treatment decisions. By using a...

Background: Skin aging is mainly associated with oxidative stress and enzymatic degradation of collagen and elastin by protease activity. Peptides have antioxidant capacity and inhibitory effects on protease enzymes. Objective: The purpose of this st...

Collagen is an essential ingredient in dietary supplements for its anti-ageing benefits, and l-cystine-based supplementation has garnered interest for its ability to improve skin condition. Our study aimed to evaluate the effects of oral supplementat...

This review aims to provide a comprehensive overview of the botany, phytochemical composition, and dermatological effects of Cydonia oblonga (CO), with a particular focus on its therapeutic mechanisms across various skin conditions. Among the differe...

Extracellular vesicles (EVs) from the traditional medicinal herb Centella asiatica (Cica) represent a novel category of botanical actives with potential dermatological benefits, yet their clinical effects in cosmetic applications remain unexplored. T...

Eye shadows are cosmetic products widely used to enhance appearance. However, the use of raw materials contaminated with heavy metals poses potential health hazards. This study characterized 12 commercial eye shadow samples and quantified concentrati...