Advanced Functional Biomaterials in Regenerative Medicine (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 983

Special Issue Editors


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Guest Editor
Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Schnarrenbergstrasse 95, 72070 Tuebingen, Germany
Interests: bone metabolic diseases; bone biology; stem cell; bone tissue; osteogenic differentiation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Schnarrenbergstrasse 95, 72070 Tuebingen, Germany
Interests: cell culture; gene expression; medicinal and pharmaceutical chemistry; antioxidants; general surgery; reactive oxygen species; pharmacodynamics; traumatology; bone; bone metabolism; liver; diabetes; toxicology; glutathione; osteoblasts; osteoclasts; mechanotransduction; hepatocytes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite all advancements in implant design and surgical techniques, up to 10% of all broken bones worldwide still do not heal properly. The costs associated with this dilemma are enormous, weighing equally between social security spending and patient well-being. Although significant advances have been made in the last few decades in the development of new materials to overcome bone and wound healing disorders, there remains a high unmet medical need to address unhealed fractures. Through this Special Issue collection, we hope to compile new ideas to develop new biomaterials that can promote bone and tissue regeneration. This may include the functional adaptation of biomaterial design; improved adjustment of mechanical properties; changes in surface structures, internal porosity, or the material property itself; active drug, synthetic mRNA, or exosome release from the implant, etc., as they can directly affect the surrounding cell response (such as cell adhesion, proliferation, differentiation, etc.). Other topics include new biomaterials to improve clinical diagnosis of non-unions, treatment strategies, and early identification of risk patients. We welcome contributions on the following topics (articles, reviews, and communications):

  • New biomaterials in medical technology;
  • Bionanomaterials;
  • Biomaterial applications in the field of implants;
  • Biomaterial interaction and cells;
  • (Bio)material applications in the non-implant area;
  • Biocompatibility and biofunctionality, in vitro and in vivo tests;
  • Functional biomaterials;
  • Biomaterials as drug delivery agents.

Prof. Dr. Andreas K. Nüssler
Prof. Dr. Sabrina Ehnert
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new biomaterials in medical technology
  • bionanomaterials
  • biomaterial applications in the field of implants
  • biomaterial interaction and cells
  • (bio)material applications in the non-implant area
  • biocompatibility and biofunctionality, in vitro and in vivo tests
  • functional biomaterials
  • biomaterials as drug delivery agents

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Related Special Issue

Published Papers (1 paper)

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Review

17 pages, 1655 KB  
Review
Opportunities and Risks of Promoting Skin and Bone Healing via Implant Biofunctionalization of Extracellular Matrix Protein ECM1
by Niklas R. Braun, Andreas K. Nüssler and Sabrina Ehnert
J. Funct. Biomater. 2025, 16(10), 385; https://doi.org/10.3390/jfb16100385 - 14 Oct 2025
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Abstract
Impaired bone regeneration and wound healing represent a major clinical and socioeconomic challenge for our aging and multimorbid population. Fracture and wound healing share many common features, with transforming growth factor beta (TGF-β) being a key regulator of inflammation, angiogenesis, fibroblast activation, and [...] Read more.
Impaired bone regeneration and wound healing represent a major clinical and socioeconomic challenge for our aging and multimorbid population. Fracture and wound healing share many common features, with transforming growth factor beta (TGF-β) being a key regulator of inflammation, angiogenesis, fibroblast activation, and matrix remodeling. The dysregulation of TGF-β signaling is a hallmark of chronic wounds, excessive scar formation, and fracture non-union. Extracellular matrix protein 1 (ECM1) plays a crucial role in the activation of latent TGF-β. As a protein of the extracellular matrix, ECM1 offers ideal conditions for the biofunctionalization of bone implants or wound patches. Its mode of action has been studied mainly in fibrosis models of the liver or heart, where TGF-β acts as a driver of the disease. The controlled knock-out or overexpression of ECM1 either promoted or improved fibrosis development. In this review, we discuss how these findings can be applied to the biofunctionalization of implants to support bone and wound healing, considering the impact of TGF-β on the different healing phases. Full article
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