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Special Issues
Design, Synthesis, Detection, Diagnosis and Therapeutic Applications of Bioactive Materials
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Design, Synthesis, Detection, Diagnosis and Therapeutic Applications of Bioactive Materials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2884

Editors

Dr. Xiaoyu Mu

E-Mail Website
Guest Editor
Medical School, Tianjin University, Tianjin, China
Interests: bioactive materials; nanozymes; biosensing; diagnosis; therapeutic applications
Dr. Hao Wang

E-Mail Website
Guest Editor
Medical School, Tianjin University, Tianjin, China
Interests: precision medicine; nanozymes; targeted drug delivery; diagnosis; therapeutic applications

Special Issue Information

Dear Colleagues,

This Special Issue highlights cutting-edge advances in bioactive materials, covering their design, synthesis, detection, diagnosis, and therapeutic applications. Key material types include hydrogels (for drug delivery and tissue engineering), nanozymes (nanoparticles with enzyme-mimetic catalytic activities for tumor therapy and biosensing), biodegradable polymers (e.g., PLA/PGA for implants), stimuli-responsive materials (pH/temperature-sensitive systems for targeted release), antimicrobial coatings (silver/copper nanoparticles for infection control), 3D-printed bioinks (cell-laden scaffolds for regenerative medicine), and so on. These materials drive innovation in precision medicine, enabling smarter diagnostics, controlled therapies, and enhanced tissue regeneration.

Dr. Xiaoyu Mu
Dr. Hao Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive materials
  • nanozymes
  • hydrogels
  • stimuli-responsive materials
  • biodegradable polymers
  • 3D-printed bioinks
  • antimicrobial coatings
  • tissue engineering
  • targeted drug delivery
  • precision medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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16 pages, 7569 KB  
Article
Evaluation of Graphene as a Novel Bioactive Stent Coating: Comparative Performance and Vascular Response in Porcine Coronary Arteries
by Jacek Arkowski, Przemysław Sareło, Urszula Pasławska, Robert Pasławski and Magdalena Wawrzyńska
J. Funct. Biomater. 2026, 17(7), 313; https://doi.org/10.3390/jfb17070313 - 28 Jun 2026
Viewed by 592
Abstract
Coronary drug-eluting stents (DESs) are the current clinical standard, yet delayed endothelialization remains a critical challenge. Graphene-based coatings have emerged as promising cardiovascular biomaterials due to their favorable hemocompatibility and ability to support endothelial cell growth. In this study, we evaluated the in [...] Read more.
Coronary drug-eluting stents (DESs) are the current clinical standard, yet delayed endothelialization remains a critical challenge. Graphene-based coatings have emerged as promising cardiovascular biomaterials due to their favorable hemocompatibility and ability to support endothelial cell growth. In this study, we evaluated the in vivo performance of graphene-coated stents (GCSs) compared with commercial sirolimus-eluting stents in a Polish White swine model (n = 10). Stents were implanted into major coronary branches, with follow-up at 30 and 90 days using quantitative coronary angiography (QCA), optical coherence tomography (OCT), and cryogenic scanning electron microscopy (cryo-SEM). No systemic toxicity, mortality, thrombotic events, or ischemic complications were observed during the study period. QCA demonstrated no significant differences in percent diameter stenosis between GCSs and DESs at either 30 days (12.3 ± 6.1% vs. 8.6 ± 5.8%, p = 0.2782) or 90 days (18.3 ± 10.5% vs. 9.6 ± 6.6%, p = 0.1074). OCT analysis confirmed comparable lumen and neointimal parameters between groups, while demonstrating a favorable, although non-significant, trend toward a lower percentage of uncovered struts in GCSs. Cryo-SEM imaging demonstrated stable tissue integration and a preserved healing response surrounding GCSs. Collectively, these findings indicate that GCSs are safe and biocompatible and demonstrate mid-term vascular performance comparable to clinically used DES platforms. The presented results support further investigation of graphene-based coatings as potential surface-modification strategies for coronary stents. Full article
(This article belongs to the Special Issue Design, Synthesis, Detection, Diagnosis and Therapeutic Applications of Bioactive Materials)
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11 pages, 1596 KB  
Communication
Amino-Modified Mesoporous Bioactive Glass Adsorbed with Osteopontin Enhances Osteogenic Differentiation and Matrix Mineralization via the Erk1/2 Signaling Pathway
by Ying Yang, Kunlu Lin, Zheng Zhou, Libangxi Liu, Long Liu, Haoming Liu, Hanyue Mao and Xiaoyan Wang
J. Funct. Biomater. 2026, 17(3), 153; https://doi.org/10.3390/jfb17030153 - 19 Mar 2026
Viewed by 786
Abstract
Mesoporous bioactive glass (MBG) has been extensively studied in bone regeneration due to its excellent bioactivity and osteoconductive properties. Here, we prepared amino-modified MBG (MBG-NH2) adsorbed osteopontin (OPN) to form MBG-NH2/OPN composites, enabling the sustained release of OPN and [...] Read more.
Mesoporous bioactive glass (MBG) has been extensively studied in bone regeneration due to its excellent bioactivity and osteoconductive properties. Here, we prepared amino-modified MBG (MBG-NH2) adsorbed osteopontin (OPN) to form MBG-NH2/OPN composites, enabling the sustained release of OPN and enhancing osteoblast differentiation and mineralization capacity. Interestingly, we observed that MBG-NH2 promotes the formation of osteoid deposits and calcium deposition in vitro. Furthermore, we also found that MBG-NH2/OPN significantly enhances cell adhesion, differentiation, and mineralization. Consistent with these observations, we found the expression of the osteoblast-specific marker gene increased, including bone morphogenetic protein 2 (Bmp2) and Collagen I. Intriguingly, we also found that MBG-NH2/OPN promotes osteoblast differentiation and mineralization through activating the extracellular regulated protein kinases1/2 (Erk1/2) signaling pathway. We concluded that MBG-NH2/OPN enhances osteoblast differentiation and mineralization through the Erk1/2 pathway. These findings indicate that MBG-NH2/OPN is a new potential biomaterial for bone regeneration. Full article
(This article belongs to the Special Issue Design, Synthesis, Detection, Diagnosis and Therapeutic Applications of Bioactive Materials)
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Review

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18 pages, 1640 KB  
Review
Functionalized Biomaterials in the Investigation of the Effects of Fluid Shear Forces in the Immune Regulation of Cancer Progression and Metastasis
by Rayhaneh Afjei and Vassilios I. Sikavitsas
J. Funct. Biomater. 2026, 17(2), 81; https://doi.org/10.3390/jfb17020081 - 7 Feb 2026
Viewed by 1075
Abstract
As cancer mortality rates rise globally, malignancies have become the second leading cause of death. Recently, efforts have been made to understand the impact of the tumor microenvironment that involves fluid shear forces. Biomechanical stimulation, which uses shear stress to activate mechanosensitive ion [...] Read more.
As cancer mortality rates rise globally, malignancies have become the second leading cause of death. Recently, efforts have been made to understand the impact of the tumor microenvironment that involves fluid shear forces. Biomechanical stimulation, which uses shear stress to activate mechanosensitive ion channels, e.g., Piezo1, increases calcium influx into the intracellular space and activates T cells. Novel 3D cancer cultures with T cells have been proposed. Such models use cell/scaffold constructs to recapitulate interactions between cells and the extracellular matrix. In addition, flow perfusion bioreactors investigate the impact of fluid shear forces on immune and/or cancer cells. These bioreactors have biosensors that allow monitoring of immune cell activation. Furthermore, they provide a biomimetic environment for the study of the interaction of T cells and cancer cells. Hence, immune checkpoint inhibitors have demonstrated immunotherapeutic efficacy, but a single-target blockade has often proved insufficient. Co-delivery of CCL19 pDNA and the PD-1/PD-L1 interaction inhibitor BMS-1 using RGD-modified nanocarriers targeting tumor integrins enhanced local antitumor immunity. This review highlights recent insights into how fluid shear stress (FSS) regulates cancer progression and immune responses in three-dimensional in vitro models, with a focus on bioreactors and the surface modification of scaffold materials. Full article
(This article belongs to the Special Issue Design, Synthesis, Detection, Diagnosis and Therapeutic Applications of Bioactive Materials)
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