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Vaccines, Volume 9, Issue 5

May 2021 - 126 articles

Cover Story: Considering that SARS-CoV-2 is mainly mucosally transmitted, a therapy administered via this same route may represent a desirable approach to fight SARS-CoV-2 infection. Experience over the past few decades has clearly demonstrated that a shift from traditional needle-based to needle-free immunization can overcome a number of limitations. Therefore, in this review, we highlight the potential of using genetically modified probiotics to express SARS-CoV-2 proteins with the aim of developing candidate oral vaccines that are capable of stimulating immune responses in the gut and lung to fight COVID-19. Indeed, the crosstalk and reciprocal interaction of the gut and lung mucosa (gut–lung axis) is mediated by immune cells moving between the two districts via the bloodstream and the lymphatic ducts, leading to modulation of the immune response at both sites. View this paper.
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Articles (126)

  • Article
  • Open Access
28 Citations
4,113 Views
11 Pages

This study aimed to compare the differences in motivation to receive a COVID-19 vaccination between frontline physicians and nurses and the Taiwanese public. The associations of threat and coping appraisals, as described in Protection Motivation Theo...

  • Review
  • Open Access
56 Citations
6,980 Views
17 Pages

Influenza could circulate in parallel with COVID-19. In the context of COVID-19, some studies observed inverse associations between influenza vaccination and SARS-CoV-2 infection and clinical outcomes, while others did not. We conducted a meta-analys...

  • Article
  • Open Access
4 Citations
3,790 Views
13 Pages

Despite not being full-time health care workers, annual flu vaccination is nevertheless an important consideration for medical students. This study examined the reasons for refusing flu vaccination among medical students, a group characterized by low...

  • Article
  • Open Access
11 Citations
4,371 Views
13 Pages

Immune Responses in Laying Hens after an Infectious Bronchitis Vaccination of Pullets: A Comparison of Two Vaccination Strategies

  • Sabrina M. Buharideen,
  • Mohamed S. H. Hassan,
  • Shahnas M. Najimudeen,
  • Dongyan Niu,
  • Markus Czub,
  • Susantha Gomis and
  • Mohamed Faizal Abdul-Careem

For decades, vaccinations have been used to limit infectious bronchitis (IB) in both the broiler and layer industries. Depending on the geographical area, live attenuated vaccines are used either alone or in combination with inactivated vaccines to c...

  • Review
  • Open Access
75 Citations
7,262 Views
18 Pages

The Evolving Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Treatment

  • Patrizia Leone,
  • Antonio Giovanni Solimando,
  • Rossella Fasano,
  • Antonella Argentiero,
  • Eleonora Malerba,
  • Alessio Buonavoglia,
  • Luigi Giovanni Lupo,
  • Valli De Re,
  • Nicola Silvestris and
  • Vito Racanelli

Hepatocellular carcinoma (HCC) is one of most common cancers and the fourth leading cause of death worldwide. Commonly, HCC development occurs in a liver that is severely compromised by chronic injury or inflammation. Liver transplantation, hepatic r...

  • Article
  • Open Access
4 Citations
3,724 Views
19 Pages

Quality Verification with a Cluster−Controlled Manufacturing System to Generate Monocyte−Derived Dendritic Cells

  • Haruhiko Kawaguchi,
  • Takuya Sakamoto,
  • Terutsugu Koya,
  • Misa Togi,
  • Ippei Date,
  • Asuka Watanabe,
  • Kenichi Yoshida,
  • Tomohisa Kato,
  • Yuka Nakamura and
  • Yasuhito Ishigaki
  • + 1 author

Dendritic cell (DC) vaccines for cancer immunotherapy have been actively developed to improve clinical efficacy. In our previous report, monocyte−derived DCs induced by interleukin (IL)−4 with a low−adherence dish (low−adherent IL-4−DCs: la−IL-4−DCs)...

  • Article
  • Open Access
5 Citations
3,819 Views
14 Pages

Sow Vaccination with a Protein Fragment against Virulent Glaesserella (Haemophilus) parasuis Modulates Immunity Traits in Their Offspring

  • Sergi López-Serrano,
  • Carlos Neila-Ibáñez,
  • Mar Costa-Hurtado,
  • Yasser Mahmmod,
  • Jorge Martínez-Martínez,
  • Iván José Galindo-Cardiel,
  • Ayub Darji,
  • Fernando Rodríguez,
  • Marina Sibila and
  • Virginia Aragon

Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer’s...

  • Review
  • Open Access
60 Citations
12,239 Views
44 Pages

Evolution of Cancer Vaccines—Challenges, Achievements, and Future Directions

  • Ban Qi Tay,
  • Quentin Wright,
  • Rahul Ladwa,
  • Christopher Perry,
  • Graham Leggatt,
  • Fiona Simpson,
  • James W. Wells,
  • Benedict J. Panizza,
  • Ian H. Frazer and
  • Jazmina L. G. Cruz

The development of cancer vaccines has been intensively pursued over the past 50 years with modest success. However, recent advancements in the fields of genetics, molecular biology, biochemistry, and immunology have renewed interest in these immunot...

  • Review
  • Open Access
13 Citations
3,934 Views
11 Pages

Prevention of Congenital Cytomegalovirus Infection with Vaccines: State of the Art

  • Susanna Esposito,
  • Giulia Chiopris,
  • Giulia Messina,
  • Tiziana D’Alvano,
  • Serafina Perrone and
  • Nicola Principi

Cytomegalovirus (CMV) is the most common cause of congenital infection and non-genetic sensorineural hearing loss in childhood. Up to 2% of neonates, with the highest percentages found in developing countries, are congenitally infected with CMV. At b...

  • Communication
  • Open Access
18 Citations
6,377 Views
8 Pages

Long-Term Follow-Up of Mesothelioma Patients Treated with Dendritic Cell Therapy in Three Phase I/II Trials

  • Daphne W. Dumoulin,
  • Robin Cornelissen,
  • Koen Bezemer,
  • Sara J. Baart and
  • Joachim G. J. V. Aerts

Background: Malignant pleural mesothelioma (MPM) is a fatal neoplasm with, if untreated, poor survival of approximately nine months from diagnosis. Until recently, phase II–III immunotherapy trials did not show any significant benefit. The lack of im...

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Vaccines - ISSN 2076-393X