Special Issue "Timely Administration of the Hepatitis B Birth Dose Vaccine"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Hepatitis Virus Vaccines".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Dr. Yusuke Shimakawa
Guest Editor
Institut Pasteur
Interests: Viral hepatitis; Epidemiology; Prevention; Africa

Special Issue Information

Dear Colleagues,

To achieve the WHO’s objective to globally eliminate hepatitis B virus (HBV) infection by 2030, it is essential to prevent mother-to-child transmission of HBV. Administration of the hepatitis B vaccine to neonates, preferably within 24 hours after birth, is a key intervention recommended by the WHO to reach this goal. However, the timely administration of the hepatitis B birth dose vaccine (HepB-BD) has not been well implemented in low- and middle-income countries for multiple reasons, including a high rate of childbirth at home.

This Special Issue aims to uncover the current situation of the implementation of the HepB-BD, the challenges and facilitators for its timely administration, and potential innovations to overcome these problems. This Special Issue welcomes the submission of papers from a wide range of disciplines including basic science, clinical/epidemiological research, social/anthropological studies, and health economy.

Dr. Yusuke Shimakawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Coverage for the hepatitis B birth dose vaccine
  • Cost-effectiveness of the hepatitis B birth dose vaccination
  • Potential innovations to reach babies born at home
  • Controlled temperature chain
  • Microneedle patch
  • Qualitative research
  • Health economy Implementation science vaccine
  • Birth dose
  • Mother-to-child transmission

Published Papers (1 paper)

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Open AccessArticle
Coverage and Timeliness of Birth Dose Vaccination in Sub-Saharan Africa: A Systematic Review and Meta-Analysis
Vaccines 2020, 8(2), 301; https://doi.org/10.3390/vaccines8020301 - 11 Jun 2020
Background: Depending on the epidemiological context of each country, three vaccines are recommended by the World Health Organization (WHO) to be administered as soon as possible after birth (birth vaccines); namely, BCG, zero dose of oral polio vaccine (OPV0), and birth dose [...] Read more.
Background: Depending on the epidemiological context of each country, three vaccines are recommended by the World Health Organization (WHO) to be administered as soon as possible after birth (birth vaccines); namely, BCG, zero dose of oral polio vaccine (OPV0), and birth dose of hepatitis B vaccine (HepB-BD). The timely administration of these vaccines immediately after birth might pose significant challenges in sub-Saharan Africa, where about half of childbirths occur outside health facilities. We therefore conducted a systematic review and meta-analysis to estimate the coverage rate of these vaccines at a specific timing in neonates in sub-Saharan Africa. Methods: We searched PubMed, Embase, CINAHL, and Web of Science for studies conducted in sub-Saharan Africa and published up to March 31, 2017, which provided a coverage rate of the birth vaccines at any specific time points within 28 days after birth. Two investigators independently screened the titles and abstracts and extracted data from the eligible full-text articles. This study was registered in PROSPERO (CRD42017071269). Results: Of 7283 articles identified, we finally included 31 studies with 204,111 infants in the meta-analysis. The pooled coverage rates at day 0–1 after birth were 14.2% (95% CI: 10.1–18.9) for BCG and 1.3% (0.0–4.5) for HepB-BD. No data were available for OPV0 at day 0–1. The coverage at day 28 was 71.7% (63.7–79.2) for BCG, 60.8% (45.8–74.7) for HepB-BD, and 76.1% (67.1–84.0) for OPV0. No significant difference in the vaccine coverage was observed between infants born in healthcare facilities and those born outside facilities. Conclusions: The rates of vaccine coverage immediately after birth were very low for BCG and HepB-BD, and no data for OPV0. We need additional data to better define barriers and facilitators for the timely administration of the birth vaccines in sub-Saharan Africa, since the delay in its provision may increase the burden of these vaccine-preventable diseases. Full article
(This article belongs to the Special Issue Timely Administration of the Hepatitis B Birth Dose Vaccine)
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