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Antioxidants, Volume 14, Issue 6

June 2025 - 140 articles

Cover Story: Mood disorders are a major global concern in child psychiatry, with depressive disorder (DD) being particularly challenging. The pathophysiology of DD remains incompletely understood; however, research suggests that factors such as inflammation, neurotransmitter imbalances, altered omega-6/omega-3 ratios, and increased oxidative stress may play a role. These changes can impact cell signaling, the neurohormonal system, and the kynurenine pathway. DD often triggers suicidal thoughts and suicidal attacks, leading to preventable deaths in youth. Suicide is one of the leading causes of death among young people aged 15 to 19 worldwide, with significant regional differences. Understanding molecular mechanisms of DD can pave the way for targeted treatments and early detection of relapses. View this paper
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Articles (140)

  • Review
  • Open Access
1 Citations
2,179 Views
21 Pages

Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications

  • Jiehong Zhou,
  • Jianyu Lv,
  • Xin Chen,
  • Tian Li,
  • Jianzhong Shen,
  • Zhanhui Wang,
  • Chongshan Dai and
  • Zhihui Hao

The gut serves as the main site for nutrient digestion and absorption. Simultaneously, it functions as the body’s largest immune organ, playing a dual role in sustaining physiological equilibrium and offering immunological defense against intes...

  • Review
  • Open Access
6 Citations
7,683 Views
35 Pages

Prebiotic oligosaccharides have attracted significant interest in dermatology and skin health due to their ability to modulate the skin microbiome and microbiota–host interactions. This review offers a novel dual perspective, systematically exa...

  • Article
  • Open Access
3,387 Views
23 Pages

Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy

  • Maria D’Elia,
  • Carmen Marino,
  • Rita Celano,
  • Enza Napolitano,
  • Chiara Colarusso,
  • Rosalinda Sorrentino,
  • Anna Maria D’Ursi and
  • Luca Rastrelli

Objectives: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RE:PAIR, RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress. To explore the activity of the...

  • Article
  • Open Access
1 Citations
1,249 Views
26 Pages

Influence of Kombucha Fermentation on Antioxidant and Antimicrobial Activity of Monofloral Rapeseed Bee-Collected Pollen

  • Aleksandar Ž. Kostić,
  • Aleksandra Sknepnek,
  • Danijel D. Milinčić,
  • Uroš Gašić,
  • Sofija Kilibarda and
  • Mirjana B. Pešić

Bee-collected pollen (BCP) can serve as an excellent enhancer of functional food bioactivity, particularly when it is fermented. The aim of this study was to prepare a novel kombucha-based beverage (KPE) enriched with fermented monofloral rapeseed (B...

  • Article
  • Open Access
1 Citations
1,128 Views
14 Pages

Chemical Composition and Antioxidant Activity of Prokupac Grape Pomace Extract: Implications for Redox Modulation in Honey Bee Cells

  • Uroš Glavinić,
  • Đura Nakarada,
  • Jevrosima Stevanović,
  • Uroš Gašić,
  • Marko Ristanić,
  • Miloš Mojović and
  • Zoran Stanimirović

There is a growing interest in using agri-food by-products and a demand for natural substances that might help maintain healthy honey bee colonies. We investigated a by-product of the wine industry, a grape pomace (GP) of the autochthonous Prokupac g...

  • Article
  • Open Access
912 Views
17 Pages

SENP1 Senses Oxidative Stress to Regulate the SUMOylation Modification of ZIP8 and Maintain Zinc Transport Functions

  • Tao Liu,
  • Chang-Chun Song,
  • Fu-Xuan Duan,
  • Chong-Chao Zhong,
  • Sheng-Zan Liu,
  • Jia-Cheng Guo,
  • An-Gen Yu and
  • Zhi Luo

Zinc (Zn) is a crucial trace element in vertebrates, fulfilling a range of physiological functions, whose metabolism and homeostasis are manipulated by Zn transporter proteins. SUMOylation, a reversible post-translational modification (PTM), extensiv...

  • Article
  • Open Access
1 Citations
1,370 Views
23 Pages

Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve

  • Yang Yu,
  • Yali Shan,
  • Jiani Lu,
  • Yexing Xian,
  • Zhengshan Tang,
  • Xinyu Guo,
  • Yan Huang and
  • Xin Ni

Granulosa cell (GC) dysfunction contributes to diminished ovarian reserve (DOR). We collected GC and follicular fluid samples from the patients of normal ovarian reserve (NOR) and DOR. RNA-seq of GCs showed that cholesterol/sterol metabolism and bios...

  • Article
  • Open Access
1 Citations
1,373 Views
18 Pages

Aerobic Exercise Alleviates Cardiac Dysfunction Correlated with Lipidomics and Mitochondrial Quality Control

  • Kunzhe Li,
  • Sujuan Li,
  • Hao Jia,
  • Yinping Song,
  • Zhixin Chen and
  • Youhua Wang

Cardiac adaptations induced by aerobic exercise have been shown to reduce the risk of cardiovascular disease, and the autonomic nervous system is closely associated with the development of cardiovascular disease. Aerobic exercise intervention has bee...

  • Article
  • Open Access
1 Citations
896 Views
24 Pages

Nitric oxide (NO) is a well-known member of the reactive oxygen species (ROS) family. The extent of its concentration influences whether it produces beneficial physiological effects or harmful toxic reactions. In a blood system, NO is generally produ...

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Antioxidants - ISSN 2076-3921