Functional Food and Anti-Inflammatory Function

Topic Information

Dear Colleagues,

Functional foods are foods that offer health benefits beyond mere nutritional value. They contain bioactive components, such as vitamins, minerals, probiotics, fibre, and antioxidants, which can contribute to improving general well-being and preventing disease. In addition, foods rich in anti-oxidants, such as fruit and vegetables, help fight oxidative stress, protecting cells from damage and slowing down the ageing process. Finally, research suggests that regular inclusion of functional foods in the diet may contribute to weight management and blood glucose control, benefiting people with diabetes or metabolic problems. Promoting the use of functional foods may therefore be an effective strategy to improve public health and prevent various chronic diseases limiting inflammatory process. With an emphasis on the identification, development, and establishment of functional foods with anti-inflammatory properties through the study of the biological mechanisms that food bioactive components can express, this Topic, "Functional Food and Anti-Inflammatory Function", aims to improve the health of patients. A wide range of publications are encouraged for the reasons mentioned above, including in vitro and in vivo investigations, which are necessary to gather fresh data for upcoming clinical trials. Clinical studies will receive special consideration since they provide compelling scientific evidence for the effectiveness of novel functional foods. Ultimately, thorough assessments that can condense significant subjects are helpful in launching new scientific investigations.

Dr. Marika Cordaro
Prof. Dr. Rosanna Di Paola
Dr. Roberta Fusco
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	6.6	12.4	2012	16.9 Days	CHF 2900	Submit
BioChem biochem	-	-	2021	21.7 Days	CHF 1000	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	16.8 Days	CHF 2900	Submit
Metabolites metabolites	3.7	6.9	2011	16.1 Days	CHF 2700	Submit
Biomedicines biomedicines	3.9	6.8	2013	14.6 Days	CHF 2600	Submit

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All Antioxidants BioChem IJMS Metabolites Biomedicines

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Open AccessArticle

Inactivated Cells and Metabolites of Saccharomyces boulardii Alleviate Inflammation Damage in Caco-2 Monolayer Cells and Mice with Ulcerative Colitis

by Yuxin Jin, Zehui Niu, Menglin Feng, Huilian Che and Zhihong Liang

Antioxidants 2025, 14(6), 737; https://doi.org/10.3390/antiox14060737 - 16 Jun 2025

Viewed by 102

Abstract

Saccharomyces boulardii (S. boulardii) has attracted widespread attention due to its antimicrobial and anti-inflammatory properties. In this study, we prepared postbiotics from the heat-inactivated cells (HIC) and cell-free supernatant (CFS) of S. boulardii, with the important component L-arginine (Arg) from [...] Read more.

Saccharomyces boulardii (S. boulardii) has attracted widespread attention due to its antimicrobial and anti-inflammatory properties. In this study, we prepared postbiotics from the heat-inactivated cells (HIC) and cell-free supernatant (CFS) of S. boulardii, with the important component L-arginine (Arg) from the metabolic products included as one of the experimental groups. The results showed that in LPS-stimulated Caco-2 cells, HIC, CFS, and Arg protect intestinal epithelial barrier integrity by inhibiting the expression of TNF-α, IL-1β, and IL-6 while enhancing the expression of occludin and ZO-1 proteins. In dextran sulfate sodium (DSS)-induced colitis mice, HIC, CFS, and Arg alleviate symptoms such as weight loss and colonic damage while suppressing the upregulation of pro-inflammatory factors and the downregulation of tight junction proteins. Moreover, these postbiotics help restore the gut microbiota composition and functionality in colitis mice, with potentially superior regulatory effects compared to sulfasalazine (SASP). Overall, HIC and CFS protect the intestinal barrier function and improve DSS-induced colitis, supporting the development of functional food supplements. Full article

(This article belongs to the Topic Functional Food and Anti-Inflammatory Function)

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