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Antioxidants, Volume 13, Issue 1

January 2024 - 134 articles

Cover Story: Heavy metals pose a serious threat to human health. Recent studies have linked damage associated with heavy metal exposure to oxidative stress and aging, and have identified common pathways, such as apoptosis, endoplasmic reticulum stress, and mitochondrial stress. Chelation therapy is a traditional approach to heavy metal-induced disorders, but recently the focus has shifted to antioxidants, which have been proven to be more effective treatments. This review discusses the molecular basis of heavy metal toxicity, its correlation with aging, and its clinical significance, as well as the role of antioxidants and other protective agents against heavy metal damage, reflecting the evolving paradigm in therapeutic approaches. View this paper
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Articles (134)

  • Article
  • Open Access
1 Citations
3,107 Views
14 Pages

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells

  • Sara García-Gil,
  • Azahara Rodríguez-Luna,
  • Javier Ávila-Román,
  • Gabriela Rodríguez-García,
  • Rosa E. del Río,
  • Virginia Motilva,
  • Mario A. Gómez-Hurtado and
  • Elena Talero

22 January 2024

Ultraviolet (UV) radiation harms the skin, causing oxidative damage, inflammation, and disruption of the skin’s barrier function. There is considerable interest in identifying new natural ingredients with antioxidant and anti-inflammatory prope...

  • Review
  • Open Access
14 Citations
3,850 Views
18 Pages

A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics

  • Rosa Purgatorio,
  • Angelina Boccarelli,
  • Leonardo Pisani,
  • Modesto de Candia,
  • Marco Catto and
  • Cosimo D. Altomare

22 January 2024

Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, and cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, and curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, he...

  • Review
  • Open Access
126 Citations
18,266 Views
25 Pages

22 January 2024

Myeloperoxidase (MPO) is a heme-containing peroxidase, mainly expressed in neutrophils and, to a lesser extent, in monocytes. MPO is known to have a broad bactericidal ability via catalyzing the reaction of Cl− with H2O2 to produce a strong oxi...

  • Article
  • Open Access
8 Citations
3,681 Views
12 Pages

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway

  • So Jin Cha,
  • Seon Sook Kim,
  • Jin Hak Shin and
  • Su Ryeon Seo

22 January 2024

Peiminine is the main natural alkaloid compound extracted from the Chinese herb Fritillaria. Although peiminine is known for its antioxidant and anti-inflammatory effects in conditions such as mastitis and arthritis, its impact on inflammation induce...

  • Article
  • Open Access
12 Citations
5,349 Views
14 Pages

High Tyrosol and Hydroxytyrosol Intake Reduces Arterial Inflammation and Atherosclerotic Lesion Microcalcification in Healthy Older Populations

  • Nada Zoubdane,
  • Redha-Alla Abdo,
  • Michel Nguyen,
  • M’hamed Bentourkia,
  • Eric E. Turcotte,
  • Hicham Berrougui,
  • Tamas Fulop and
  • Abdelouahed Khalil

22 January 2024

Aging is an important risk factor for cardiovascular diseases and convincing data have shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to cardiovascular risk. The present study aimed to use 18F-F...

  • Article
  • Open Access
12 Citations
2,597 Views
19 Pages

Effects of Alkalinity Exposure on Antioxidant Status, Metabolic Function, and Immune Response in the Hepatopancreas of Macrobrachium nipponense

  • Shubo Jin,
  • Mingjia Xu,
  • Xuanbin Gao,
  • Sufei Jiang,
  • Yiwei Xiong,
  • Wenyi Zhang,
  • Hui Qiao,
  • Yan Wu and
  • Hongtuo Fu

21 January 2024

The oriental river prawn Macrobrachium nipponense is an important freshwater economic species in China, producing huge economic benefits. However, M. nipponense shows lower alkali tolerance than fish species, thus genetic selection is urgently needed...

  • Article
  • Open Access
5 Citations
2,747 Views
28 Pages

Evaluation of the Effect of an Olive Phenolic Extract on the Secondary Shelf Life of a Fresh Pesto

  • Beatrice Sordini,
  • Stefania Urbani,
  • Sonia Esposto,
  • Roberto Selvaggini,
  • Luigi Daidone,
  • Gianluca Veneziani,
  • Maurizio Servili and
  • Agnese Taticchi

20 January 2024

Recent advances in the olive oil sector aim to develop sustainable strategies for the valorisation of mechanical extraction co-products as a rich source of bioactive compounds with antioxidant and antimicrobial activities. In this work, we studied th...

  • Review
  • Open Access
13 Citations
4,969 Views
25 Pages

Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification

  • Paula Cadenas-Garrido,
  • Ailén Schonvandt-Alarcos,
  • Lourdes Herrera-Quintana,
  • Héctor Vázquez-Lorente,
  • Alicia Santamaría-Quiles,
  • Jon Ruiz de Francisco,
  • Marina Moya-Escudero,
  • David Martín-Oliva,
  • Sandra M. Martín-Guerrero and
  • César Rodríguez-Santana
  • + 2 authors

20 January 2024

Antioxidant defenses in biological systems ensure redox homeostasis, regulating baseline levels of reactive oxygen and nitrogen species (ROS and RNS). Oxidative stress (OS), characterized by a lack of antioxidant defenses or an elevation in ROS and R...

  • Article
  • Open Access
1 Citations
2,041 Views
13 Pages

Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

  • Antonio Mancini,
  • Andrea Silvestrini,
  • Fabio Marcheggiani,
  • Emmanuele Capobianco,
  • Sonia Silvestri,
  • Erminia Lembo,
  • Patrick Orlando,
  • Flavia Beccia,
  • Nicola Nicolotti and
  • Nicola Panocchia
  • + 1 author

20 January 2024

Oxidative stress (OS) is implicated in several chronic diseases. Extra-cellular superoxide dismutase (ec-SOD) catalyses the dismutation of superoxide anions with a protective role in endothelial cells. In chronic kidney disease (CKD), OS and thyroid...

  • Article
  • Open Access
5 Citations
3,000 Views
15 Pages

Telomere Maintenance Is Associated with Type 2 Diabetes Remission in Response to a Long-Term Dietary Intervention without Non-Weight Loss in Patients with Coronary Heart Disease: From the CORDIOPREV Randomized Controlled Trial

  • Ana Ojeda-Rodriguez,
  • Juan F. Alcala-Diaz,
  • Oriol Alberto Rangel-Zuñiga,
  • Antonio P. Arenas-de Larriva,
  • Francisco M. Gutierrez-Mariscal,
  • Jose D. Torres-Peña,
  • Marina Mora-Ortiz,
  • Juan L. Romero-Cabrera,
  • Raul M. Luque and
  • Jose M. Ordovas
  • + 4 authors

19 January 2024

In order to evaluate whether telomere maintenance is associated with type 2 diabetes remission, newly diagnosed type 2 diabetes patients without glucose-lowering treatment (183 out of 1002) from the CORDIOPREV study (NCT00924937) were randomized to c...

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Antioxidants - ISSN 2076-3921