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Diagnostics, Volume 15, Issue 6

March-2 2025 - 144 articles

Cover Story: Chronic kidney disease in diabetes (DKD) affects up to 50% of people with type 2 diabetes (T2D), leading to high morbidity, mortality, and healthcare costs. The standard of care relies on the estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio (uACR), but these measures are highly variable due to factors like diet and exercise, limiting their accuracy. More precise prognostic tools are needed to improve DKD risk assessment in T2D. This study evaluates the biomarker-based PromarkerD test against eGFR and uACR for predicting kidney decline in people with T2D. PromarkerD demonstrated superior predictive accuracy, identifying 84% of cases that were missed by standard tests, with better risk stratification and fewer false positives. View this paper
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Articles (144)

  • Article
  • Open Access
1,263 Views
14 Pages

The Zucker Diabetic Fatty Rat as a Model for Vascular Changes in Diabetic Kidney Disease: Characterising Hydronephrosis

  • Amy McDermott,
  • Nathalie Sarup Panduro,
  • Iman Taghavi,
  • Hans Martin Kjer,
  • Stinne Byrholdt Søgaard,
  • Michael Bachmann Nielsen,
  • Jørgen Arendt Jensen and
  • Charlotte Mehlin Sørensen

Background/Objectives: Diabetic kidney disease (DKD) is a significant concern for global healthcare, particularly in individuals with diabetes. The Zucker rat strain is a commonly used model of type 2 diabetes, despite awareness that this animal can...

  • Case Report
  • Open Access
1 Citations
2,504 Views
11 Pages

Cladosporium species novum Invasive Pulmonary Infection in a Patient with Post-COVID-19 Syndrome and AIDS

  • Milorad Bijelović,
  • Nikola Gardić,
  • Aleksandra Lovrenski,
  • Danijela Petrović,
  • Gordana Kozoderović,
  • Vesna Lalošević,
  • Vuk Vračar and
  • Dušan Lalošević

Background and Clinical Significance: Since the prevalence of fungal lung infections is increasing, certain agents, such as Cladosporium spp., have emerged as unexpected causes. Cladosporium spp. fungi are ubiquitous in environments such as soil, fru...

  • Interesting Images
  • Open Access
885 Views
4 Pages

Orbital Neurolymphomatosis in Patient with CNS Lymphoma

  • Tara Shooshani,
  • Michael Han,
  • Jeremiah P. Tao,
  • Samuel J. Spiegel and
  • Maria Del Valle Estopinal

Neurolymphomatosis (NL) is a rare manifestation of hematologic malignancies, characterized by a neoplastic infiltration of the peripheral nervous system and cranial nerves (CNs). Non-Hodgkin lymphomas (NHLs) account for 90% of NL cases, while acute l...

  • Article
  • Open Access
1,469 Views
14 Pages

The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging

  • Adrian T. Huber,
  • Joanna Bartkowiak,
  • Robin Seitz,
  • Benedikt Bernhard,
  • Martina Boscolo Berto,
  • Giancarlo Spano,
  • Benedikt Wagner,
  • Verena C. Obmann,
  • Lukas Ebner and
  • Inga A. S. Todorski
  • + 12 authors

Background/Objectives: The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI. Methods: This retrospective study included patients who underwent cardi...

  • Review
  • Open Access
1 Citations
2,803 Views
18 Pages

The Role of Autopsy in Diagnosing Fatal Chest Injuries in Road Traffic Accidents: A Literature Review

  • Matteo Antonio Sacco,
  • Maria Cristina Verrina,
  • Saverio Gualtieri,
  • Agostinho Santos,
  • Bárbara Ferreira Mendes,
  • Alessandro Pasquale Tarallo,
  • Aurora Princi,
  • Stefano Lombardo,
  • Pietrantonio Ricci and
  • Isabella Aquila

Road accidents are one of the leading causes of death worldwide, with significant repercussions on public health and the global economy. Fatal accidents can cause injuries in various anatomical areas with different dynamics. The thorax is one of the...

  • Article
  • Open Access
1,247 Views
12 Pages

Impact of Radiologist Experience on AI Annotation Quality in Chest Radiographs: A Comparative Analysis

  • Malte Michel Multusch,
  • Lasse Hansen,
  • Mattias Paul Heinrich,
  • Lennart Berkel,
  • Axel Saalbach,
  • Heinrich Schulz,
  • Franz Wegner,
  • Joerg Barkhausen and
  • Malte Maria Sieren

Background/Objectives: In the burgeoning field of medical imaging and Artificial Intelligence (AI), high-quality annotations for training AI-models are crucial. However, there are still only a few large datasets, as segmentation is time-consuming, ex...

  • Review
  • Open Access
3 Citations
2,807 Views
16 Pages

Deep Learning Models to Detect Anterior Cruciate Ligament Injury on MRI: A Comprehensive Review

  • Michele Mercurio,
  • Federica Denami,
  • Dimitra Melissaridou,
  • Katia Corona,
  • Simone Cerciello,
  • Domenico Laganà,
  • Giorgio Gasparini and
  • Roberto Minici

Magnetic resonance imaging (MRI) is routinely used to confirm the suspected diagnosis of anterior cruciate ligament (ACL) injury. Recently, many studies explored the role of artificial intelligence (AI) and deep learning (DL), a sub-category of AI, i...

  • Case Report
  • Open Access
1 Citations
2,247 Views
14 Pages

Background and clinical significance: Large-cell neuroendocrine carcinoma (LCNEC) of the cervix is considered a rare type of cancer: it represents <1% of invasive cervical cancers. The optimal treatment protocol is not fully established because of...

  • Case Report
  • Open Access
1 Citations
1,701 Views
10 Pages

A Silent Threat: Internal Carotid Artery Hypoplasia and Its Role in Basilar Artery Aneurysm Formation—A Case Study

  • Paula Mežvinska,
  • Artis Brokāns,
  • Sergejs Pavlovičs,
  • Matīss Dravnieks,
  • Ardis Platkājis and
  • Arturs Balodis

Background and Clinical Significance: Hypoplasia of the internal carotid artery (ICA) is a rare vascular anomaly, with an estimated incidence of less than 0.01%. This condition can result in reduced blood flow to the anterior circulation, often compe...

  • Article
  • Open Access
2 Citations
2,360 Views
20 Pages

Background: Parkinson’s disease (PD) is one of the most prevalent, widespread, and intricate neurodegenerative disorders. According to the experts, at least 1% of people over the age of 60 are affected worldwide. In the present time, the early...

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Diagnostics - ISSN 2075-4418