- Editorial
10 Citations
3,004 Views
4 Pages
Mitochondria: From Physiology to Pathology
- Francesco Bruni
Over the past decade, the role of mitochondria has extended beyond those tasks for which these organelles are historically known [...]
- 3.4Impact Factor
- 6.0CiteScore
- 17 daysTime to First Decision
Life, Volume 11, Issue 9
September 2021 - 127 articles
Cover Story: The article by Nordeen et al. reviews the background and context of basic studies that have contributed to the ground-breaking clinical trials employing high testosterone therapy to treat castrate-resistant prostate cancer. Studies from the bench will continue to contribute to the optimization of high testosterone therapy and the identification of exploitable vulnerabilities that accompany the adaptation made by cancer cells to manipulate their androgen environment. View this paper
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Articles (127)
- Article
5 Citations
3,466 Views
12 Pages
The Procoagulant Activity of Emoxilane®: A New Appealing Therapeutic Use in Epistaxis of the Combination of Sodium Hyaluronate, Silver Salt, α-tocopherol and D-panthenol
- Raffaella Belvedere,
- Nunzia Novizio,
- Daniela Eletto,
- Amalia Porta,
- Antonino Bagnulo,
- Andrea Cerciello,
- Umberto Di Maio and
- Antonello Petrella
Epistaxis is one of the most frequent hemorrhages resulting from local or systemic factors. Its management without hospitalization has prompted an interest in locally applied hemostatic agents. Generally, the therapy approaches involve sprays or crea...
- Article
3 Citations
3,060 Views
13 Pages
Computational Insights into the Interaction between Cytoadherence Receptor gC1qR and the DBLβ12 Domain of a Plasmodium falciparum PfEMP1 Ligand
- Rowaida Bakri,
- Mohd Rehan,
- Hina Shamshad and
- Abdul Hafiz
Human receptor gC1qR is a 32 kD protein that mediates the cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) to human brain microvascular endothelial cells (HBMEC) and platelets. The cytoadherence of IEs to gC1qR has been associated w...
- Article
7 Citations
4,140 Views
16 Pages
Hematopoietic Prostaglandin D Synthase Inhibitor PK007 Decreases Muscle Necrosis in DMD mdx Model Mice
- Sai Yarlagadda,
- Christina Kulis,
- Peter G. Noakes and
- Mark L. Smythe
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and wasting due to the lack of dystrophin protein. The acute phase of DMD is characterized by muscle necrosis and increased levels of the pro-inflammatory mediator, pro...
- Review
97 Citations
12,773 Views
16 Pages
Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most important risk factors for cardiovascular and cerebrovascular complications. It is currently thought to be the result of disturbances in a number of neural, rena...
- Review
56 Citations
14,764 Views
12 Pages
Anemia in Sports: A Narrative Review
- Marc-Tudor Damian,
- Romana Vulturar,
- Cristian Cezar Login,
- Laura Damian,
- Adina Chis and
- Anca Bojan
Recent years have brought about new understandings regarding the pathogenesis of anemia in sports. From hemodilution and redistribution considered to contribute to the so-called “sports anemia” to iron deficiency caused by increased demands, dietary...
- Review
23 Citations
5,797 Views
20 Pages
Secreted Effectors Modulating Immune Responses to Toxoplasma gondii
- Tadakimi Tomita,
- Rebekah B. Guevara,
- Lamisha M. Shah,
- Andrews Y. Afrifa and
- Louis M. Weiss
Toxoplasma gondii is an obligate intracellular parasite that chronically infects a third of humans. It can cause life-threatening encephalitis in immune-compromised individuals. Congenital infection also results in blindness and intellectual disabili...
- Article
8 Citations
3,624 Views
16 Pages
Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
- Tihana Maric,
- Ana Katusic Bojanac,
- Ana Matijevic,
- Marcello Ceppi,
- Marco Bruzzone,
- Evangelini Evgeni,
- Tea Petrovic,
- Iwona Wójcik,
- Irena Trbojevic-Akmacic and
- Gordan Lauc
- + 2 authors
Background: Male infertility is increasingly becoming a health and demographic problem. While it may originate from congenital or acquired diseases, it can also result from environmental exposure. Hence, the complexity of involved molecular mechanism...
- Article
7 Citations
4,590 Views
28 Pages
Metabolomic Response of the Creeping Wood Sorrel Oxalis corniculata to Low-Dose Radiation Exposure from Fukushima’s Contaminated Soil
- Ko Sakauchi,
- Wataru Taira and
- Joji M. Otaki
The biological consequences of the Fukushima nuclear accident have been intensively studied using the pale grass blue butterfly Zizeeria maha and its host plant, the creeping wood sorrel Oxalis corniculata. Here, we performed metabolomic analyses of...
- Article
4 Citations
2,299 Views
16 Pages
The Complementarity Principle—One More Step towards Analytical Docking on the Example of Dihydrofolate Reductase Complexes
- Vladimir Potemkin and
- Maria Grishina
New approaches to assessing the “enzyme–ligand” complementarity, taking into account hydrogens, have been proposed. The approaches are based on the calculation of three-dimensional maps of the electron density of the receptor–ligand complexes. The ac...
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Life - ISSN 2075-1729