- Article
Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3
- Tao Li,
- Jieying Ma,
- Zehua Xu,
- Shuang Wang,
- Nan Wang,
- Shulin Shao,
- Wei Yang,
- Lin Huang and
- Yihan Liu
Hirudin and its variants, as strong inhibitors against thrombin, are present in the saliva of leeches and are recognized as potent anticoagulants. However, their yield is far from the clinical requirement up to now. In this study, the production of h...

