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Open AccessArticle

The Role of the HOXA Gene Family in Acute Myeloid Leukemia

1,2,3,†, 1,2,3,†, 1,2,3, 1,2,3, 1,2,3 and 1,2,3,*
1
Department of Hematologic Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
2
State Key Laboratory of Oncology in South China, Guangzhou 510060, China
3
Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
*
Author to whom correspondence should be addressed.
Si-Liang Chen and Zhe-Yuan Qin Contributed equally.
Genes 2019, 10(8), 621; https://doi.org/10.3390/genes10080621
Received: 22 July 2019 / Revised: 6 August 2019 / Accepted: 14 August 2019 / Published: 16 August 2019
(This article belongs to the Section Human Genomics and Genetic Diseases)
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PDF [5088 KB, uploaded 16 August 2019]
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Abstract

The HOXA gene family is associated with various cancer types. However, the role of HOXA genes in acute myeloid leukemia (AML) have not been comprehensively studied. We compared the transcriptional expression, survival data, and network analysis of HOXA-associated signaling pathways in patients with AML using the ONCOMINE, GEPIA, LinkedOmics, cBioPortal, and Metascape databases. We observed that HOXA2-10 mRNA expression levels were significantly upregulated in AML and that high HOXA1-10 expression was associated with poor AML patient prognosis. The HOXA genes were altered in ~18% of the AML samples, either in terms of amplification, deep deletion, or elevated mRNA expression. The following pathways were modulated by HOXA gene upregulation: GO:0048706: embryonic skeletal system development; R-HSA-5617472: activation of HOX genes in anterior hindbrain development during early embryogenesis; GO:0060216: definitive hemopoiesis; hsa05202: transcriptional mis-regulation in cancer; and GO:0045638: negative regulation of myeloid cell differentiation, and they were significantly regulated due to alterations affecting the HOXA genes. This study identified HOXA3-10 genes as potential AML therapeutic targets and prognostic markers. View Full-Text
Keywords: HOXA gene family; acute myeloid leukemia; transcription factor; prognostic value; molecular functions; bioinformatics integration analysis HOXA gene family; acute myeloid leukemia; transcription factor; prognostic value; molecular functions; bioinformatics integration analysis
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Chen, S.-L.; Qin, Z.-Y.; Hu, F.; Wang, Y.; Dai, Y.-J.; Liang, Y. The Role of the HOXA Gene Family in Acute Myeloid Leukemia. Genes 2019, 10, 621.

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