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Open AccessArticle

Global Investigation of Cytochrome P450 Genes in the Chicken Genome

1
Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
2
National Engineering Laboratory for Animal Breeding, and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing 100193, China
3
College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
*
Author to whom correspondence should be addressed.
Genes 2019, 10(8), 617; https://doi.org/10.3390/genes10080617
Received: 21 June 2019 / Revised: 5 August 2019 / Accepted: 9 August 2019 / Published: 14 August 2019
(This article belongs to the Section Animal Genetics and Genomics)
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Abstract

Cytochrome P450 (CYP) superfamily enzymes are broadly involved in a variety of physiological and toxicological processes. However, genome-wide analysis of this superfamily has never been investigated in the chicken genome. In this study, genome-wide analyses identified 45 chicken CYPs (cCYPs) from the chicken genome, and their classification and evolutionary relationships were investigated by phylogenetic, conserved protein motif, and gene structure analyses. The comprehensive evolutionary data revealed several remarkable characteristics of cCYPs, including the highly divergent and rapid evolution of the cCYPs, and the loss of cCYP2AF in the chicken genome. Furthermore, the cCYP expression profile was investigated by RNA-sequencing. The differential expression of cCYPs in developing embryos revealed the involvement of cCYPs in embryonic development. The significantly regulated cCYPs suggested its potential role in hepatic metabolism. Additionally, 11 cCYPs, including cCYP2AC1, cCYP2C23a, and cCYP2C23b, were identified as estrogen-responsive genes, which indicates that these cCYPs are involved in the estrogen-signaling pathway. Meanwhile, an expression profile analysis highlights the divergent role of different cCYPs. These data expand our view of the phylogeny and evolution of cCYPs, provide evolutionary insight, and can help elucidate the roles of cCYPs in physiological and toxicological processes in chicken. View Full-Text
Keywords: Cytochrome P450; phylogenetic tree; gene structure; CYP2AC1; chicken Cytochrome P450; phylogenetic tree; gene structure; CYP2AC1; chicken
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Ren, J.; Yang, L.; Li, Q.; Zhang, Q.; Sun, C.; Liu, X.; Yang, N. Global Investigation of Cytochrome P450 Genes in the Chicken Genome. Genes 2019, 10, 617.

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