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Special Issue "Animal Modeling in Cancer"
Deadline for manuscript submissions: closed (31 August 2019).
Dr. Vladimir Korinek Website E-Mail
Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, Department of Cell and Developmental Biology, Prague, Czech Republic
Interests: Cell biology, genetics, gastrointestinal tract, intestinal epithelium, stem cells, colorectal cancer, Wnt signaling, TCF/LEF proteins, mouse models, gene targeting
The understanding of pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share similar genetic, physiological and behavioral composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries in many biomedical disciplines.
Currently, there is a high interest in gene manipulation techniques as they have become a fundamental research tool to generate organisms that simulate diseases characteristics on which new research and treatments can be applied. Over the years, a large availability of methods to generate animal models has been developed including conditional alleles production, gene knock-ins, and RNA interference technologies that greatly contributed to our knowledge why and how diseases are initiated, developed, and, eventually, cured.
In the recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer effectively. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose and many technological breakthroughs are changing the way that cancer is studied and analysed.
In this Special Issue, we would like to collect a set of research articles and reviews that focus on the generation of cancer animal models that are used to understand the disease and contribute to design and test new drugs for cancer prevention or treatment in mice and in other vertebrate model organisms.
Dr. Vladimír Kořínek
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mouse models
- non-mouse models
- gene editing
- stem cells
- solid tumors
- hematologic malignancies