Special Issue "Domestication Genetics"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editor

Guest Editor
Dr. Anna V Kukekova Website E-Mail
Univesity of Illinois

Special Issue Information

Dear Colleagues,

The beginning of plant and animal domestication in the early Holocene gave rise to multidimensional changes in human society. A few ancient centers of animal domestication produced most of the agriculturally important species which predetermined human population expansion and on which we continue to rely today. In many species, the timing of domestication as well as the number of domestication events and their geographical origin(s), remain questions of interest, despite long being investigated through the archeological and historical records. Since the development of genomic tools, genomics has emerged as another voice in this debate. Today, the genomes of many common domesticated species have been sequenced and their wild progenitors, existing or extinct, identified. The emergence of next-generation sequencing technologies has presented opportunities to sequence many individuals within species and has begun to reveal the complex history of populations and breeds. The identification of genomic signatures of selection for morphological and production-related traits has been facilitated by the analysis of a growing wealth of such sequencing data. These analyses have revealed that living in close proximity to humans induced changes in the genomes of domesticated species associated with adaption to new environments, climates, and to husbandry itself, in addition to the effects of artificial selection for desirable traits. The primary differences between domesticated animals and their wild progenitors are related to behavior, with domesticated species usually displaying a tame disposition, higher stress resistance, and increased social tolerance. Although understanding the genetic bases of these changes remains a challenge, the molecular processes associated with domesticated behavior have begun to emerge. Animal domestication, which started over 15,000 years ago with the domestication of dogs from wolves, is arguably the most influential and longest-running experiment in the human history, and with genomics it has reached a new epoch. This Special Issue will present recent advances in animal domestication research that are uncovering the genetic changes associated with domestication that have yielded such important consequences for our own species.

Dr. Anna V Kukekova
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • domestication
  • breed
  • quantitative trait loci
  • selective sweep
  • dog
  • cow
  • pig
  • sheep
  • goat
  • camel

Published Papers (1 paper)

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Open AccessArticle
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4
Genes 2019, 10(8), 615; https://doi.org/10.3390/genes10080615 - 13 Aug 2019
Retinol binding protein 4 (RBP4), mainly secreted by the liver and adipocytes, is a transporter of vitamin A. RBP4 has been shown to be involved in several pathophysiological processes, such as obesity, insulin resistance, and cardiovascular risk. Reports have indicated the high expression [...] Read more.
Retinol binding protein 4 (RBP4), mainly secreted by the liver and adipocytes, is a transporter of vitamin A. RBP4 has been shown to be involved in several pathophysiological processes, such as obesity, insulin resistance, and cardiovascular risk. Reports have indicated the high expression levels of RBP4 in cystic follicles. However, the role of RBP4 in mammalian follicular granulosa cells (GCs) remains largely unknown. To illustrate the molecular pathways associated with the effects of RBP4 on GCs, we used high-throughput sequencing to detect differential gene expression in GCs overexpressing RBP4. A total of 113 differentially expressed genes (DEGs) were identified in RBP4-overexpressing GCs, and they included 71 upregulated and 42 downregulated genes. The differential expressions of the top 10 DEGs were further confirmed by real-time quantitative polymerase chain reaction. Pathway analysis indicated that the DEGs are mostly involved in oxidative phosphorylation, Parkinson’s disease, non-alcoholic fatty liver disease, Huntington’s disease, cardiac muscle contraction, Alzheimer’s disease, fatty acid biosynthesis, AMP-activated protein kinase signaling pathway, and insulin signaling pathway. Genes in these pathways should be useful for future studies on GCs. Altogether, the results of our study establish a framework for understanding the potential functions of RBP4 in porcine GCs. Full article
(This article belongs to the Special Issue Domestication Genetics)
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