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The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study

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Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul 96020-220, Brazil
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Laboratory of Clinical Neuroscience, Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul 96015-560, Brazi
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Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul 96015-560, Brazil
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Post-graduate Program Pediatrics Child Health, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil
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Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90035-007, Brazil
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National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, São Paulo 05403-900, Brazil
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Program in Genetics and Molecular Biology Universidade Federal do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil
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Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, 01246-903, Brasil
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Author to whom correspondence should be addressed.
Genes 2019, 10(8), 626; https://doi.org/10.3390/genes10080626
Received: 26 May 2019 / Revised: 23 July 2019 / Accepted: 13 August 2019 / Published: 20 August 2019
(This article belongs to the Section Human Genomics and Genetic Diseases)
Background: It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. Methods: Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health. Results: We observed an association between rs4916723 (MIR9-2) and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130–0.944; p = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698–0.987; p = 0.035). rs4938723 (MIR34B/C) was not associated with any evaluated outcome. Conclusion: The study suggests that MIR9-2 may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems. View Full-Text
Keywords: mental health; genetics; microRNA; birth cohort mental health; genetics; microRNA; birth cohort
MDPI and ACS Style

Tovo-Rodrigues, L.; Quinte, G.C.; Brum, C.B.; Ghisleni, G.; Bastos, C.R.; Oliveira, I.O.; Barros, F.C.; Barros, A.J.D.; Santos, I.S.; Rohde, L.A.; Hutz, M.H.; Matijasevich, A. The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study. Genes 2019, 10, 626.

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