Table of Contents
Cells, Volume 7, Issue 11 (November 2018)
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Cover Story (view full-size image) The heterogeneity of clinical manifestations in chronic Chagas disease is one of the features of [...] Read more. The heterogeneity of clinical manifestations in chronic Chagas disease is one of the features of this disease that still need to be unraveled by science. It is still unknown what causes some patients infected with Trypanossoma cruzi (T. cruzi) to develop cardiac and/or severe digestive clinical outcomes, while others patients do not present symptoms related to these pathologies. It is well known that interactions between immune cells such as monocytes and lymphocytes drive immune responses. Further, the co-stimulatory molecules expressed by monocytes induce T lymphocytes activation, thereby triggering cellular immune responses. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, understanding the role of co-stimulatory molecules can elucidate important aspects of T. cruzi infection and of the development of cardiac changes inherent to the disease that could be crucial to clarify Chagas disease dynamics.