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Cells 2018, 7(11), 210; https://doi.org/10.3390/cells7110210

Systemic Hypertension Effects on the Ciliary Body and Iris. An Immunofluorescence Study with Aquaporin 1, Aquaporin 4, and Na+, K+ ATPase in Hypertensive Rats

1
Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain
2
Instituto de Investigación y Ciencias de Puerto del Rosario, 35600 Puerto del Rosario, Spain
3
Servicio de Oftalmología, Hospital Universitario de Canarias, 38200 La Laguna, Spain
*
Author to whom correspondence should be addressed.
Received: 4 October 2018 / Revised: 8 November 2018 / Accepted: 9 November 2018 / Published: 13 November 2018
(This article belongs to the Special Issue Aquaporins)
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Abstract

Aquaporin 1 (AQP1) and aquaporin 4 (AQP4) have been identified in the eye as playing an essential role in the formation of the aqueous humor along with the Na+/K+ ATPase pump. Different authors have described the relationship between blood pressure, aqueous humor production, and intraocular pressure with different conclusions, with some authors supporting a positive correlation between blood pressure and intraocular pressure while others disagree. The aim of this work was to study the effect of high blood pressure on the proteins involved in the production of aqueous humor in the ciliary body (CB) and iris. For this purpose, we used the eyes of spontaneously hypertensive rats (SHR) and their control Wistar-Kyoto rats (WKY). Immunofluorescence was performed in different eye structures to analyze the effects of hypertension in the expression of AQP1, AQP4, and the Na+/K+ ATPase α1 and α2 subunits. The results showed an increase in AQP1 and Na+/K+ ATPase α1 and a decrease in AQP4 and Na+/K+ ATPase α2 in the CB of SHR, while an increase in AQP4 and no significant differences in AQP1 were found in the iris. Therefore, systemic hypertension produced changes in the proteins implicated in the movement of water in the CB and iris that could influence the production rate of aqueous humor, which would be affected depending on the duration of systemic hypertension. View Full-Text
Keywords: aquaporin 1; aquaporin 4; Na+/K+ ATPase; iris; ciliary body; hypertension aquaporin 1; aquaporin 4; Na+/K+ ATPase; iris; ciliary body; hypertension
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González-Marrero, I.; Hernández-Abad, L.G.; Carmona-Calero, E.M.; Castañeyra-Ruiz, L.; Abreu-Reyes, J.A.; Castañeyra-Perdomo, A. Systemic Hypertension Effects on the Ciliary Body and Iris. An Immunofluorescence Study with Aquaporin 1, Aquaporin 4, and Na+, K+ ATPase in Hypertensive Rats. Cells 2018, 7, 210.

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