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Retraction published on 3 August 2019, see Cells 2019, 8(8), 819.
Open AccessArticle

Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes

Department of Biomedical and Biotechnological Science, Section of Physiology, University of Catania, Via Santa Sofia, 97-95123 Catania, Italy
Author to whom correspondence should be addressed.
Cells 2018, 7(11), 197;
Received: 16 September 2018 / Revised: 25 October 2018 / Accepted: 31 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Aquaporins)
The development in digital screen technology has exponentially increased in the last decades, and many of today’s electronic devices use light-emitting diode (LED) technology producing very strong blue light (BL) waves. Long-term exposure at LED-BL seems to have an implication in the dehydration of the epidermis, in the alterations of shape and number of the keratinocytes, and in the aging of the skin. Aquaporins (AQPs) are water membrane channels that permeate both water and glycerol and play an important role in the hydration of epidermis, as well as in proliferation and differentiation of keratinocytes. Thus, we have hypothesized that AQPs could be involved in the aging of the skin exposed to LED-BL. Therefore, we have examined the expression of AQPs in human keratinocytes exposed to LED-BL at dose of 45 J/cm2, used as an in vitro model to produce the general features of photo aging of the skin. The aim was to verify if LED-BL induces changes of the basal levels of AQPs. The keratinocytes exposure to LED-BL produced an increase of reactive oxygen species (ROS), an activation of 8-hydroxy-2’-deoxyguanosine (8-OHdG), an alteration of proliferating cell nuclear antigen (PCNA), and a down-regulation of AQP1, 3 and 9. These findings are preliminary evidences that may be used as starting points for further investigations about the mechanistic involvement of AQP1, 3, and 9 in LED-BL-induced skin aging. View Full-Text
Keywords: aquaporin; blue light; photo aging; oxidative stress; keratinocytes; skin aquaporin; blue light; photo aging; oxidative stress; keratinocytes; skin
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MDPI and ACS Style

Avola, R.; Graziano, A.C.E.; Pannuzzo, G.; Cardile, V. Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes. Cells 2018, 7, 197.

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