Special Issue "Tubulin: Structure, Functions and Roles in Disease"
Deadline for manuscript submissions: closed (28 February 2019).
Interests: molecular and cell biology of microtubular cytoskeleton; gamma-tubulin and its role in microtubule nucleation and organization; gamma-tubulin as filament forming tubulin and its scaffolding and sequestration role in nuclear processes
Interests: computational drug design; systems biology of cancer and neurodegenerative diseases; tubulin
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Drug-Protein Interactions and Mechanisms of Action by Structural Modifications Driving Protein Function
Special Issue in International Journal of Molecular Sciences: Molecular Insights in Psychiatry
Microtubules are assembled from highly conserved α and β-tubulin dimers and perform multiple cellular functions in intracellular transport, in determining cell shape and polarity and in the cell division. Microtubules are essential also for assembly of specialized structures of cilia, flagella or centrioles. Tubulin exists in forms of different isotypes with spatially and temporally regulated expression and some isotypes are differentially expressed in normal and neoplastic cells. For example, tubulin βIII isotype is overexpressed in many metastatic cancers and serves as a prognostic marker in certain types of cancer. Understanding mutations in isotypes of tubulin expressed in invasive tumors and differing in binding of anti-cancer drugs will help to uncover potentially relevant molecular targets for design of novel drugs. Moreover, α/β-tubulins are altered by posttranslational modifications which change microtubule behavior also through modification of interaction with microtubule associated proteins including motors and effectors of microtubule dynamics. Understanding of usage of tubulin isotypes and posttranslational modifications in physiological and pathological conditions will help to uncover role of tubulins in regulation of cell division, in centrosomal functions and in processes, such as ciliogenesis or neuronal differentiation. This Special Issue of Cells should improve our understanding of a link of tubulin code which programs microtubules for specific functions with human pathologies. There is a growing number of bacterial tubulins that evolved wide range of cytoskeletal functions. Ability to assemble protofilaments and fibrilar structures characteristics of prokaryotic tubulins is preserved for γ-tubulin a conserved member of eukaryotic tubulin superfamily specialized for microtubule nucleation and with much less understood functions in nuclear and cell cycle related processes. Characterization of tubulins which are on an evolutionary cusp between prokaryotes and eukaryotes will also help our understanding how structure of tubulins is related to their multiple cellular functions under normal and pathological conditions.
Dr. Pavla Binarová
Prof. Jack Tusczynski
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- structure and functions
- posttranslational modifications
- physiological roles and pathologies