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Telomere Length Calibration from qPCR Measurement: Limitations of Current Method
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Cells 2018, 7(11), 193; https://doi.org/10.3390/cells7110193

Leukocyte Telomere Length and Chronic Conditions in Older Women of Northeast Brazil: A Cross-Sectional Study

1
Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59078970, Brazil
2
Office of Public Health Studies, University of Hawaii at Manoa, Honolulu, HI 96822, USA
3
Département de Médecine sociale et préventive, École de santé publique, Université de Montréal, C.P. 6128, succ. Centre-Ville, Montréal, QC H3C 3J7, Canada
4
Departamento de Biologia Celular e Genética, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59078970, Brazil
5
Programa Multicêntrico de Pós-graduação em Ciências Fisiológicas (PMPGCF), Núcleo de Estudos de Patologias Inflamatórias e Infecciosas (NEPii) and Faculdade de Medicina de Diamantina—FAMED, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100000, Brazil
6
Campus Universitário Natal, Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59078970, Brazil
*
Author to whom correspondence should be addressed.
Received: 22 September 2018 / Revised: 17 October 2018 / Accepted: 25 October 2018 / Published: 2 November 2018
(This article belongs to the Special Issue The Role of Telomere Biology in Aging and Human Disease)
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Abstract

This study assessed whether telomere length is related to chronic conditions, cardiovascular risk factors, and inflammation in women aged 65 to 74 from Northeast Brazil. Participants were selected from two sources, a representative sample of the International Mobility in Aging Study (n = 57) and a convenience sample (n = 49) recruited at senior centers. Leukocyte telomere length was measured by quantitative polymerase chain reaction from blood samples in 83 women. Natural log-transformed telomere/single copy gene ratio was used as the dependent variable in the analysis. Blood analyses included inflammatory markers (high-sensitivity C-reactive protein and interleukin-6), total, low-density lipoprotein and high-density lipoprotein cholesterol, triglycerides, glucose and glycosylated hemoglobin. Self-rated health, chronic conditions, cardiovascular risk factors and inflammatory markers were not associated with telomere length. No significant independent association was found between telomere length and anthropometric measures or blood markers, even after adjusting for age, education and adverse childhood events among these older women in Northeast Brazil. Our results did not confirm the hypothesis that chronic conditions, cardiovascular risk factors or inflammation are associated with shorter telomere length in these women who have exceptional survival relative to the life expectancy of their birth cohort. View Full-Text
Keywords: telomeres; women; aging; cardiovascular risk; chronic diseases; inflammation telomeres; women; aging; cardiovascular risk; chronic diseases; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Oliveira, B.S.; Pirkle, C.M.; Zunzunegui, M.V.; Batistuzzo de Medeiros, S.R.; Thomasini, R.L.; Guerra, R.O. Leukocyte Telomere Length and Chronic Conditions in Older Women of Northeast Brazil: A Cross-Sectional Study. Cells 2018, 7, 193.

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