Next Article in Journal
Aquaporins: More Than Functional Monomers in a Tetrameric Arrangement
Previous Article in Journal
Molecular Basis of Aquaporin-7 Permeability Regulation by pH
Previous Article in Special Issue
Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency
Article Menu

Article Versions

Export Article

Open AccessReview
Cells 2018, 7(11), 208;

Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells

Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, 31151, Korea
Author to whom correspondence should be addressed.
Received: 22 October 2018 / Revised: 3 November 2018 / Accepted: 5 November 2018 / Published: 10 November 2018
(This article belongs to the Special Issue Targeting Hedgehog Signaling in Cancer)
PDF [1258 KB, uploaded 10 November 2018]   |   Review Reports


The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many fundamental processes, including embryonic development and tissue homeostasis. Moreover, emerging evidence has suggested that aberrant activation of Hh is associated with neoplastic transformations, malignant tumors, and drug resistance of a multitude of cancers. At the molecular level, it has been shown that Hh signaling drives the progression of cancers by regulating cancer cell proliferation, malignancy, metastasis, and the expansion of cancer stem cells (CSCs). Thus, a comprehensive understanding of Hh signaling during tumorigenesis and development of chemoresistance is necessary in order to identify potential therapeutic strategies to target various human cancers and their relapse. In this review, we discuss the molecular basis of the Hh signaling pathway and its abnormal activation in several types of human cancers. We also highlight the clinical development of Hh signaling inhibitors for cancer therapy as well as CSC-targeted therapy.
Keywords: Hedgehog signaling pathway; cancer therapy; cancer stem cells Hedgehog signaling pathway; cancer therapy; cancer stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Sari, I.N.; Phi, L.T.H.; Jun, N.; Wijaya, Y.T.; Lee, S.; Kwon, H.Y. Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells. Cells 2018, 7, 208.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top