Next Article in Journal
Exploring the Effect of Rotenone—A Known Inducer of Parkinson’s Disease—On Mitochondrial Dynamics in Dictyostelium discoideum
Previous Article in Journal
A Novel Circular RNA Generated by FGFR2 Gene Promotes Myoblast Proliferation and Differentiation by Sponging miR-133a-5p and miR-29b-1-5p
Article Menu

Export Article

Open AccessReview
Cells 2018, 7(11), 200;

The Role of Co-Stimulatory Molecules in Chagas Disease

Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil
René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais 30.190-009, Brazil
National Institute of Science and Technology in Tropical Diseases, INCT-DT, Belo Horizonte, Minas Gerais 31270-901, Brazil
Author to whom correspondence should be addressed.
Received: 10 October 2018 / Revised: 29 October 2018 / Accepted: 5 November 2018 / Published: 7 November 2018
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
Full-Text   |   PDF [1147 KB, uploaded 7 November 2018]   |  


Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics. View Full-Text
Keywords: Chagas disease; monocytes; lymphocytes; co-stimulatory molecules Chagas disease; monocytes; lymphocytes; co-stimulatory molecules

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Pinto, B.F.; Medeiros, N.I.; Fontes-Cal, T.C.M.; Naziazeno, I.M.; Correa-Oliveira, R.; Dutra, W.O.; Gomes, J.A.S. The Role of Co-Stimulatory Molecules in Chagas Disease. Cells 2018, 7, 200.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top