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Cells 2018, 7(11), 200; https://doi.org/10.3390/cells7110200

The Role of Co-Stimulatory Molecules in Chagas Disease

1
Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil
2
René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais 30.190-009, Brazil
3
National Institute of Science and Technology in Tropical Diseases, INCT-DT, Belo Horizonte, Minas Gerais 31270-901, Brazil
*
Author to whom correspondence should be addressed.
Received: 10 October 2018 / Revised: 29 October 2018 / Accepted: 5 November 2018 / Published: 7 November 2018
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
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Abstract

Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics. View Full-Text
Keywords: Chagas disease; monocytes; lymphocytes; co-stimulatory molecules Chagas disease; monocytes; lymphocytes; co-stimulatory molecules
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pinto, B.F.; Medeiros, N.I.; Fontes-Cal, T.C.M.; Naziazeno, I.M.; Correa-Oliveira, R.; Dutra, W.O.; Gomes, J.A.S. The Role of Co-Stimulatory Molecules in Chagas Disease. Cells 2018, 7, 200.

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