Special Issue "Epidermal Growth Factor Receptor Signaling"
Deadline for manuscript submissions: 30 June 2019
Prof. Zhixiang Wang
Signal Transduction Research Group, Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
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Interests: ErbB receptors; cell signaling; protein trafficking; breast cancer; small GTPases and cell cycle
The epidermal growth factor receptor (EGFR), like other receptor tyrosine kinases (RTKs), regulates key events in cell growth, differentiation, survival and migration. Aberrant signaling from EGFR has been implicated in many diseases. EGFR is historically the prototypical RTK. It was the first of this large family of transmembrane receptors to be cloned, and the first for which a clear connection between aberrant receptor function and cancer could be drawn.
There are four members in the ErbB receptor family, also known as the EGFR family or type I receptor family, including EGFR or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3 and ErbB4/Her4. The ErbB receptor family is unique among various groups of RTKs in that ErbB3 has impaired kinase activity, while ErbB2 does not have a direct ligand. Therefore, heterodimerization is an important mechanism that allows the activation of all ErbB receptors in response to ligand stimulation. The activated ErbB receptors bind to many signaling proteins and stimulate the activation of many signaling pathways, including the Ras-Raf-Mek-ERK, PI3K-Akt-Tor, PLC-γ1, STAT and Src pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the ErbB receptors. Through the control of these diverse signaling networks, ErbB receptors regulate many critical cellular processes, such as cell proliferation, cell differentiation, cell survival, cell metabolism, cell migration, and cell cycle. Binding of EGF to EGFR also stimulates the rapid internalization of EGFR. EGFR endocytosis and EGFR-mediated cell signaling are mutually regulated.
In spite of significant advances in our understanding of EGFR signaling and trafficking, some critical knowledge is still lacking. Novel signaling pathways and cell functions are continuously identified as regulated by EGFR family. EGFR family receptor are still intensively explored for developing novel therapies targeting various cancers. This Special Issue will cover the recent progress in all of the areas related to EGFR family signaling and cancer.
Prof. Zhixiang Wang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ErbB receptor
- cell signaling
- cell cycle
- targeted cancer therapy