Special Issue "Unconventional Protein Secretion in Development and Disease"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (1 June 2019)
The constitutive or regulated secretory pathway characterized by vesicular traffic from the endoplasmic reticulum, through the Golgi apparatus and towards the plasma membrane has been long recognized for all eukaryotic cells. However, an increasing number of proteins are also found to be secreted in an unconventional manner, in modes that are insensitive to inhibitors of conventional exocytosis and/or use a routes that bypasses the Golgi apparatus. Prominent examples of these include the fibroblast growth factor 2 (FGF2) and interleukin-1β (IL-1β), and even membrane proteins such as integrin-alpha and the cystic fibrosis transmembrane conductor (CFTR). Unconventional secretion may be important for cellular homeostasis as well as waste clearance and in some instances secreted proteins are known to play roles in intercellular signalling. Cellular mechanisms underlying the multiple modes of unconventional protein secretion range from a recently deciphered form of plasma membrane translocation to processes involving the generation of secretory autophagosomes, secretory lysosomes, ectosomes, exosomes and other extracellular microvesicles. The mechanisms underlying processes are not yet fully known or understood and this is an active area of study in cell biology.
Importantly, unconventional protein secretion has been shown to play important roles during development, such as in the secretion of the transcription factor Engrailed and the cell adhesion molecule integrin-α. Unconventional secretion of pathological factors such as α-Synuclein, Tau, Huntingtin, TDP-43 and Superoxide dismutase 1 (SOD1) likely play significant roles in the pathological spread of important neurodegenerative diseases. Unconventional secretion is important for immune modulation and contributes to cancer cell/tissue secretomes. These unconventionally secreted proteins could have therefore have oncogenic roles and may be useful cancer biomarkers.
In this special issue of Cells, we invite your contributions, either in the form of original research articles, reviews, or shorter “Perspective” articles on all aspects related to the theme of “Unconventional Protein Secretion in Development and Disease”. Articles with mechanistic and functional insights from a cell and molecular biological perspective are particularly welcome. Relevant topics include, but are not limited to
- Unconventional secretion of specific cargo molecules in mammalian and plant cells
- Mechanisms of unconventional secretion in eukaryotes
- Unconventional secretion during embryonic development
- Unconventional secretion in immune function and diseases
- Unconventional secretion in cancer
- Unconventional secretion in neurodegenerative diseases
Manuscript Submission Information
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- unconventional secretion