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Cancers, Volume 12, Issue 1 (January 2020) – 241 articles
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Cover Story (view full-size image) The introduction of immunotherapy marks a step forward in the quest for a cure for multiple [...] Read more. The introduction of immunotherapy marks a step forward in the quest for a cure for multiple myeloma. Monoclonal antibodies that target CD38 (daratumumab) and CS1 (elotuzumab) are highly effective and safe options for young and elderly patients. Daratumumab has been included in many regimens and moved from the relapsed to the frontline setting. Furthermore, antibody-drug conjugates such as belantamab mafodotin (GSK2857916) are also under clinical evaluation. Active immunotherapy, aimed at awakening patients’ immune systems against myeloma cells, is of great interest, with bispecific T cell engagers such as AMG420 proving to be effective in heavily pretreated patients in clinical trials. A number of challenges still remain, including the following: finding the correct timing for these agents during the disease course, understanding the mechanisms of resistance, and identifying the antigens to target myeloma cells. View this paper